Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

[18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function

Version 1 : Received: 22 February 2022 / Approved: 16 March 2022 / Online: 16 March 2022 (09:26:16 CET)

A peer-reviewed article of this Preprint also exists.

Triviño-Ibáñez, E.M.; Jiménez-Rodríguez, B.M.; Rudolphi-Solero, T.; García-Rivero, E.Y.; Rodríguez-Fernández, A.; Llamas-Elvira, J.M.; Gómez-Río, M.; Morales-García, C. [18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function. Diagnostics 2022, 12, 835. Triviño-Ibáñez, E.M.; Jiménez-Rodríguez, B.M.; Rudolphi-Solero, T.; García-Rivero, E.Y.; Rodríguez-Fernández, A.; Llamas-Elvira, J.M.; Gómez-Río, M.; Morales-García, C. [18F]FDG PET/CT in Short-Term Complications of COVID-19: Metabolic Markers of Persistent Inflammation and Impaired Respiratory Function. Diagnostics 2022, 12, 835.

Journal reference: Diagnostics 2022, 12, 835
DOI: 10.3390/diagnostics12040835

Abstract

Evaluation of the usefulness of [18F]FDG-PET/CT in the short-term follow-up of patients admitted for COVID-19 pneumonia and to explore the association of findings with clinical prognostic markers. Prospective study included 20 patients admitted to hospital with COVID-19 pneumonia between November 2020 and March 2021. Clinical and laboratory test findings were gathered at admission, 48-72h post-admission, and 2-3 months post-discharge. [18F]FDG-PET/CT and respiratory function tests were performed at 2-3 months post-discharge. Lung volumes (TLC), spirometry (FVC, FEV1), lung diffusion capacity for carbon monoxide (DLCO), and respiratory muscle strength were measured. PET/CT images were qualitatively and semi-quantitatively interpreted. Volumetric [18F]FDG-PET/CT results were correlated with laboratory test and respiratory parameters. Eleven [18F]FDG-PET/CT (55%) were positive. The main finding was hypermetabolic lymphade-nopathy in the mediastinum (90.9%). SUVpeak of the target mediastinum lesion was correlated with neutrophil and lymphocyte counts. Eleven (55%) patients had impaired respiratory function, most frequently a reduced DLCO (35%). SUVpeak was positively correlated with %predict-ed-DLCO values. Pulmonary TLG was negatively correlated with %predicted-DLCO and TLC values. In the short-term follow-up of patients hospitalized for COVID-19 pneumonia, [18F]FDG-PET/CT findings revealed significant detectable inflammation in lungs and mediastinal lymph nodes that correlated with pulmonary function impairment in more than half of the patients.

Keywords

COVID-19; FDG-PET/CT; respiratory function test; complications; inflammatory; SARS-CoV-2

Subject

MEDICINE & PHARMACOLOGY, Other

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