Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Pediatric Patients from Panama

Lizette Carmen Gutierrez; Viridiana Saenz; Danilo Franco; Marlene Castillo; Brechla Moreno; Ediner Fuentes; Zeuz Capitan-Barrios; Sandra López-Vergès; Juan Miguel Pascale; Nestor Sosa; Leyda Ábrego

doi:10.20944/preprints202203.0187.v2

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202203.0187.v2

Preprint Article Version 2 Preserved in Portico This version is not peer-reviewed

Detection of Human Parechovirus a in Respiratory, Gastrointestinal, and Neurological Clinical Samples of Pediatric Patients from Panama

Lizette Carmen Gutierrez

Version 1 : Received: 11 March 2022 / Approved: 14 March 2022 / Online: 14 March 2022 (11:28:42 CET)
Version 2 : Received: 26 April 2022 / Approved: 27 April 2022 / Online: 27 April 2022 (08:07:52 CEST)

A peer-reviewed article of this Preprint also exists.

Gutierrez, L., Sáenz, V., Franco, D., Moreno, B., Fuentes-Campos, E., Capitan-Barrios, Z., ... & Ábrego, L. (2023). Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014–2015). Virology Journal, 20(1), 302. Gutierrez, L., Sáenz, V., Franco, D., Moreno, B., Fuentes-Campos, E., Capitan-Barrios, Z., ... & Ábrego, L. (2023). Detection of parechovirus A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients from Panama (2014–2015). Virology Journal, 20(1), 302.

Abstract

Human Parechoviruses, officially known as Parechovirus A (PeV-A), is associated with mild gastrointestinal and respiratory illness in young children, however, they may also give rise to Central Nervous System (CNS) infections and neonatal sepsis. While studies have delved into the detection of PeV-A in different populations, the detection of PeV-A in Hispanic populations in Latin American countries is not well-known. The aim of this study was to determine the presence of PeV-A in respiratory, gastrointestinal, and neurological clinical samples of pediatric patients in Panama. Two hundred samples of pediatric patients with a negative diagnosis for the main respiratory viruses, rotavirus and neurological viruses such as herpesvirus, enterovirus and cytomegalovirus, collected between 2014 and 2015, were analyzed by real-time RT-PCR. Eight positive PeV-A infections were detected, 2 in respiratory samples, 5 in stool samples and one detected in cerebrospinal fluid. This is the fisrt report of PeV-A in Panamá.

Keywords

human parechovirus; HPeV; PeV-A; Panama; gastrointestinal infection; respiratory infection

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Received: 27 April 2022
Commenter: Leyda Abrego
Commenter's Conflict of Interests: Author

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