Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Vitamin D on Graft-Versus-Host Disease

Version 1 : Received: 24 February 2022 / Approved: 3 March 2022 / Online: 3 March 2022 (10:02:45 CET)

A peer-reviewed article of this Preprint also exists.

Rodríguez-Gil, A.; Carrillo-Cruz, E.; Marrero-Cepeda, C.; Rodríguez, G.; Pérez-Simón, J.A. Effect of Vitamin D on Graft-Versus-Host Disease. Biomedicines 2022, 10, 987. Rodríguez-Gil, A.; Carrillo-Cruz, E.; Marrero-Cepeda, C.; Rodríguez, G.; Pérez-Simón, J.A. Effect of Vitamin D on Graft-Versus-Host Disease. Biomedicines 2022, 10, 987.

Journal reference: Biomedicines 2022, 10, 987
DOI: 10.3390/biomedicines10050987

Abstract

The different cell subsets of the immune system express vitamin D receptor (VDR). Through VDR, vitamin D exerts different functions which influences on immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies have explored the impact of vitamin D levels on the outcome of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results have been confirmed in a prospective cohorts trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies has also been explored. Considering this dual effect both on the immune system as well as on tumor cells in patients with hematologic malignancies, vitamin D might be useful in this setting both to decrease graft-versus-host disease and relapse rates.

Keywords

vitamin D; calcifediol; cailcitriol; graft-versus-host disease; vitamin D receptor (VDR)

Subject

MEDICINE & PHARMACOLOGY, Oncology & Oncogenics

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.