Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Vitamin D on Graft-Versus-Host Disease

Alfonso Rodríguez Gil
ORCID logo ,
Estrella Carrillo-Cruz
,
Cristina Marrero-Cepeda
,
Guillermo Rodriguez
,
Jose A. Pérez-Simón
* ORCID logo
Version 1 : Received: 24 February 2022 / Approved: 3 March 2022 / Online: 3 March 2022 (10:02:45 CET)

A peer-reviewed article of this Preprint also exists.

Rodríguez-Gil, A.; Carrillo-Cruz, E.; Marrero-Cepeda, C.; Rodríguez, G.; Pérez-Simón, J.A. Effect of Vitamin D on Graft-Versus-Host Disease. Biomedicines 2022, 10, 987. Rodríguez-Gil, A.; Carrillo-Cruz, E.; Marrero-Cepeda, C.; Rodríguez, G.; Pérez-Simón, J.A. Effect of Vitamin D on Graft-Versus-Host Disease. Biomedicines 2022, 10, 987.

Abstract

The different cell subsets of the immune system express vitamin D receptor (VDR). Through VDR, vitamin D exerts different functions which influences on immune responses, as previously shown in different preclinical models. Based on this background, retrospective studies have explored the impact of vitamin D levels on the outcome of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications, especially graft-versus-host disease. These results have been confirmed in a prospective cohorts trial, although further studies are required to confirm this data. In addition, the role of vitamin D on the treatment of hematologic malignancies has also been explored. Considering this dual effect both on the immune system as well as on tumor cells in patients with hematologic malignancies, vitamin D might be useful in this setting both to decrease graft-versus-host disease and relapse rates.

Keywords

vitamin D; calcifediol; cailcitriol; graft-versus-host disease; vitamin D receptor (VDR)

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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