Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses such as SARS-CoV-2

Version 1 : Received: 26 February 2022 / Approved: 2 March 2022 / Online: 2 March 2022 (07:17:08 CET)

A peer-reviewed article of this Preprint also exists.

Cano-Vicent, A.; Hashimoto, R.; Takayama, K.; Serrano-Aroca, Á. Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2. Polymers 2022, 14, 1483. Cano-Vicent, A.; Hashimoto, R.; Takayama, K.; Serrano-Aroca, Á. Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2. Polymers 2022, 14, 1483.

Journal reference: Polymers 2022, 14, 1483
DOI: 10.3390/polym14071483

Abstract

The current pandemic is urgently demanding to discover alternative materials capable of inactivate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus 2019 (COVID-19) disease. Calcium alginate is a crosslinked hydrophilic biopolymer with an immense range of biomedical applications due to its excellent chemical, physical and biological properties. In this study, the cytotoxicity and antiviral activity of calcium alginate in the form of films were studied. The results showed that these films are biocompatible in human keratinocytes and are capable of inactivating enveloped viruses such as bacteriophage phi 6 with a 1.43-log reduction (94.92% viral inactivation) and SARS-CoV-2 Delta variant with a 1.64-log reduction (96.94% viral inactivation) in virus titers. The antiviral activity of these calcium alginate films can be attributed to its negative charge density that may bind to viral envelopes inactivating membrane receptors.

Keywords

calcium alginate; SARS-CoV-2; bacteriophage; phi 6; biomaterials; films; hydrogels

Subject

MATERIALS SCIENCE, Biomaterials

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