Biological Activity of Propolis: An Update

Antibiotic resistance was described soon discovery of penicillin by Fleming. In recent years, there has been increasing research interest in the development of alternatives to address this problem. Natural products, mainly, have long been considered as sources of drugs, and a great part of pharmaceuticals available in modern medicine are directly or indirectly derived from natural sources. propolis been used to treat human diseases since ancient times, propolis, is a natural resinous mixture produced by honeybees (Apis mellifera) from collected parts of plants, he is increasingly recognized by their wide range of biological and pharmacological properties, As anti- infective agent, combination synergy with standard antibiotics could be very promising alternative strategy