Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Omicron Variant: Secrets Behind the Great Escape Artist

Version 1 : Received: 16 February 2022 / Approved: 18 February 2022 / Online: 18 February 2022 (05:23:18 CET)

A peer-reviewed article of this Preprint also exists.

Hertanto DM, Sutanto H, Lusida MI et al. The genomic and clinical features of the COVID-19 Omicron variant: a narrative review [version 1; peer review: awaiting peer review]. F1000Research 2022, 11:353 (https://doi.org/10.12688/f1000research.110647.1) Hertanto DM, Sutanto H, Lusida MI et al. The genomic and clinical features of the COVID-19 Omicron variant: a narrative review [version 1; peer review: awaiting peer review]. F1000Research 2022, 11:353 (https://doi.org/10.12688/f1000research.110647.1)

Abstract

The 2019 Coronavirus Disease (COVID-19) is a major cause of morbidity and mortality worldwide. Since late November 2021, Omicron variant has emerged as the primary cause of COVID-19 and caused a huge increase in the reported incidence around the world. To date, 32-34 spike mutations have been reported, 15 of which were located in the receptor-binding domain that interacts with the cell surface of the host cells, while the rest were located in the N-terminal domain and around the Furin cleavage site. At present, both the genomic and clinical profiles of this novel variant are being investigated. Here, we aim to discuss the recent reports on the transmissibility and severity of Omicron variant from both the genetic and clinical perspectives. Afterward, we also take the chance to deliver our personal view on the topic.

Keywords

COVID-19; pandemic; SARS-CoV-2; Omicron variant; emerging disease; global health; virus; genome; mutation

Subject

Biology and Life Sciences, Virology

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