Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation

Version 1 : Received: 11 January 2022 / Approved: 28 January 2022 / Online: 28 January 2022 (14:57:08 CET)

How to cite: J.C. Long, M.; Miranda Herrera, P.A.; Aye, Y. Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints 2022, 2022010440 (doi: 10.20944/preprints202201.0440.v1). J.C. Long, M.; Miranda Herrera, P.A.; Aye, Y. Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints 2022, 2022010440 (doi: 10.20944/preprints202201.0440.v1).

Abstract

Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are underactive debate. However, in our opinion it is becoming increasingly likely that electrophiles can rewire cellular signaling processes at endogenous levels. Attention is turning more to understanding how nuanced electrophile signaling in cells is. In this perspective, we describe recent work from our laboratory that has started to inform on different levels of context-specific regulation of proteins by electrophiles. We discuss the relevance of these data to the field, and to the broader application of electrophile signaling to precision medicine development, beyond the traditional views of their pleiotropic cytotoxic roles.

Keywords

electrophiles; signaling; profiling; drug mechanism; drug discovery; T-REX

Subject

LIFE SCIENCES, Other

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