Version 1
: Received: 11 January 2022 / Approved: 28 January 2022 / Online: 28 January 2022 (14:57:08 CET)
How to cite:
J.C. Long, M.; Miranda Herrera, P.A.; Aye, Y. Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints2022, 2022010440. https://doi.org/10.20944/preprints202201.0440.v1
J.C. Long, M.; Miranda Herrera, P.A.; Aye, Y. Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints 2022, 2022010440. https://doi.org/10.20944/preprints202201.0440.v1
J.C. Long, M.; Miranda Herrera, P.A.; Aye, Y. Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints2022, 2022010440. https://doi.org/10.20944/preprints202201.0440.v1
APA Style
J.C. Long, M., Miranda Herrera, P.A., & Aye, Y. (2022). Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation. Preprints. https://doi.org/10.20944/preprints202201.0440.v1
Chicago/Turabian Style
J.C. Long, M., Pierre A. Miranda Herrera and Yimon Aye. 2022 "Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation" Preprints. https://doi.org/10.20944/preprints202201.0440.v1
Abstract
Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are underactive debate. However, in our opinion it is becoming increasingly likely that electrophiles can rewire cellular signaling processes at endogenous levels. Attention is turning more to understanding how nuanced electrophile signaling in cells is. In this perspective, we describe recent work from our laboratory that has started to inform on different levels of context-specific regulation of proteins by electrophiles. We discuss the relevance of these data to the field, and to the broader application of electrophile signaling to precision medicine development, beyond the traditional views of their pleiotropic cytotoxic roles.
Keywords
electrophiles; signaling; profiling; drug mechanism; drug discovery; T-REX
Subject
Medicine and Pharmacology, Pharmacy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
