Full Genome Analysis of Circulating DENV-2 in Senegal Reveals a Regional Diversification Into Separate Clades

Idrissa Dieng; Amadou Diallo; Mignane Ndiaye; Moussa Moise Diagne; Safietou Sankhe; Marie Henriette Ndione; Amadou Alpha Sall; Cheikh Loucoubar; Ousmane Faye; Oumar Faye

doi:10.20944/preprints202201.0057.v1

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preprints.org > biology and life sciences > virology > doi: 10.20944/preprints202201.0057.v1

Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

Full Genome Analysis of Circulating DENV-2 in Senegal Reveals a Regional Diversification Into Separate Clades

^* ,

Marie Henriette Ndione

Version 1 : Received: 3 January 2022 / Approved: 6 January 2022 / Online: 6 January 2022 (09:56:19 CET)

A peer-reviewed article of this Preprint also exists.

Dieng, I, Diallo, A, Ndiaye, M, et al. Full genome analysis of circulating DENV-2 in Senegal reveals a regional diversification into separate clades. J Med Virol. 2022; 94: 5593- 5600. doi:10.1002/jmv.28027 Dieng, I, Diallo, A, Ndiaye, M, et al. Full genome analysis of circulating DENV-2 in Senegal reveals a regional diversification into separate clades. J Med Virol. 2022; 94: 5593- 5600. doi:10.1002/jmv.28027

Abstract

To assess the genetic diversity of circulating dengue virus 2 in Senegal in 2018 we performed molecular characterization by complete genome sequencing and performing phylogenetic analysis. Sequenced strains belong to Cosmopolitan genotype of DENV-2 we observed intra-genotype variability leading to a divergence in two clades with differential geographic distribution. We report two variants namely; the “Northern variant” harbouring three nonsynonymous mutations (V1183M, R1405K, P2266T) located respectively on NS2A, NS2B and NS4A and the “Western variant” with two nonsynonymous mutations (V1185E, V3214E) located respectively in the NS2A gene and the NS5 gene. Findings calls for in depth in vitro and functional study to elucidate the impact of observed mutations on viral fitness, spread, epidemiology and disease outcome.

Keywords

Dengue virus; complete genome; Cosmopolitan genotype; Senegal; 2018; Regional diversification

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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