Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Airborne Alt a 1 Dynamic and Its Relationship With the Airborne Dynamics of Alternaria Conidia and Pleosporales Spores

Version 1 : Received: 16 December 2021 / Approved: 21 December 2021 / Online: 21 December 2021 (13:55:09 CET)

A peer-reviewed article of this Preprint also exists.

De Linares, C.; Navarro, D.; Puigdemunt, R.; Belmonte, J. Airborne Alt a 1 Dynamic and Its Relationship with the Airborne Dynamics of Alternaria Conidia and Pleosporales Spores. J. Fungi 2022, 8, 125. De Linares, C.; Navarro, D.; Puigdemunt, R.; Belmonte, J. Airborne Alt a 1 Dynamic and Its Relationship with the Airborne Dynamics of Alternaria Conidia and Pleosporales Spores. J. Fungi 2022, 8, 125.

Abstract

Fungal spores are universal atmospheric components associated to allergic reactions. Alternaria (Ascomycota) is considered the most allergenic spore taxa. Alt a 1 is the major allergen of Alternaria and is present also in other Pleosporales. In this study, standard Hirst-based sampling and analyzing methods for measuring spore daily concentrations of Alternaria, Curvularia, Drechslera-Helminthosporium, Epicoccum, Leptosphaeria, Pithomyces, Pleospora and Stemphyllium (all included in the taxon Pleosporales) have been used besides two high-volume samplers, Burkard Cyclone (2017) and MCV CAV-A/mb (2019-2020), and ELISA Kits for measuring the allergen. The detection and quantification of Alt a 1 was only possible in the samples from the MCV sampler. Although Alt a 1 was better correlated with Alternaria spores than with Pleosporales spores, the three of them showed high correlations. It is shown, for the first time, a high and significant correlation of Alt a 1 with temperature, a negative one with relative humidity and no correlation with precipitation. The aerobiological monitoring of these three elements ensures the best information for understanding the affectation to allergy sufferers but, if not possible, as a minimum public health service aiming at the detection, treatment and prevention of allergy, the study of the airborne Alternaria spores should be ensured.

Keywords

Allergens; Alt a 1; Alternaria; Pleosporales; fungal spores; aerobiological samplers.

Subject

Biology and Life Sciences, Immunology and Microbiology

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