Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study

Version 1 : Received: 30 November 2021 / Approved: 6 December 2021 / Online: 6 December 2021 (15:16:36 CET)
Version 2 : Received: 3 January 2022 / Approved: 5 January 2022 / Online: 5 January 2022 (10:35:07 CET)

How to cite: Hoptman, M.J.; Tural, U.; Lim, K.O.; Javitt, D.C.; Oberlin, L.E. Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study. Preprints 2021, 2021120080 (doi: 10.20944/preprints202112.0080.v1). Hoptman, M.J.; Tural, U.; Lim, K.O.; Javitt, D.C.; Oberlin, L.E. Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study. Preprints 2021, 2021120080 (doi: 10.20944/preprints202112.0080.v1).

Abstract

Schizophrenia is widely seen as a disorder of dysconnectivity. Neuroimaging studies have examined both structural and functional connectivity in the disorder, but these modalities have rarely been integrated directly. We scanned 29 patients with schizophrenia and 25 healthy control subjects and acquired resting state fMRI and diffusion tensor imaging. The Functional and Tractographic Connectivity Analysis Toolbox (FATCAT) was used to estimate functional and structural connectivity of the default mode network. Correlations between modalities were investigated, and multimodal connectivity scores (MCS) were created using principal components analysis. Nine of 28 possible region pairs showed consistent (>80%) tracts across participants. Correlations between modalities were found among those with schizophrenia for the prefrontal cortex, posterior cingulate, and lateral temporal lobes with frontal and parietal regions, consistent with frontotemporoparietal network involvement in the disorder. In patients, MCS values correlated with several aspects of the Positive and Negative Syndrome Scale, positively with those involving inwardly directed psychopathology, and negatively with those involving external psychopathology. In this preliminary sample, we found FATCAT to be a useful toolbox to directly integrate and examine connectivity between imaging modalities. A consideration of conjoint structural and functional connectivity can provide important information about the network mechanisms of schizophrenia.

Keywords

DTI; resting state; schizophrenia; FATCAT; tractography

Subject

MEDICINE & PHARMACOLOGY, Psychiatry & Mental Health studies

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.