Version 1
: Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (14:56:06 CET)
How to cite:
Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints2021, 2021110367. https://doi.org/10.20944/preprints202111.0367.v1
Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints 2021, 2021110367. https://doi.org/10.20944/preprints202111.0367.v1
Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints2021, 2021110367. https://doi.org/10.20944/preprints202111.0367.v1
APA Style
Vertecchi, E., Rizzo, A., & Salvati, E. (2021). Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints. https://doi.org/10.20944/preprints202111.0367.v1
Chicago/Turabian Style
Vertecchi, E., Angela Rizzo and Erica Salvati. 2021 "Telomere Targeting Approaches in Cancer: Over the Length Maintenance." Preprints. https://doi.org/10.20944/preprints202111.0367.v1
Abstract
Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere’s dysfunction impinges on intracellular signalling pathways, in particular DNA damage signalling and repair affecting cancer cell survival and proliferation. This review summarizes and discusses about the recent findings in anti-cancer drug development targeting different “telosome” components.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
