Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Telomere Targeting Approaches in Cancer: Over the Length Maintenance.

Version 1 : Received: 18 November 2021 / Approved: 19 November 2021 / Online: 19 November 2021 (14:56:06 CET)

How to cite: Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints 2021, 2021110367 (doi: 10.20944/preprints202111.0367.v1). Vertecchi, E.; Rizzo, A.; Salvati, E. Telomere Targeting Approaches in Cancer: Over the Length Maintenance.. Preprints 2021, 2021110367 (doi: 10.20944/preprints202111.0367.v1).

Abstract

Telomeres are crucial structures that preserve genome stability. Their progressive erosion over rounds of DNA duplication determines senescence of cells and organisms. Telomere length homeostasis is critical for cancer development then telomere maintenance mechanisms are established targets in cancer treatment. Besides telomere elongation, telomere’s dysfunction impinges on intracellular signalling pathways, in particular DNA damage signalling and repair affecting cancer cell survival and proliferation. This review summarizes and discusses about the recent findings in anti-cancer drug development targeting different “telosome” components.

Keywords

telomeres; shelterins; cancer; G-quadruplex ligands

Subject

BIOLOGY, Other

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