Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Case Study for the Region of Norte de Santander (Colombia)

Version 1 : Received: 27 October 2021 / Approved: 28 October 2021 / Online: 28 October 2021 (15:16:38 CEST)

A peer-reviewed article of this Preprint also exists.

Contreras-Ropero, J.E.; Ruiz-Roa, S.L.; García-Martínez, J.B.; Urbina-Suarez, N.A.; López-Barrera, G.L.; Barajas-Solano, A.F.; Zuorro, A. A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia). Appl. Sci. 2022, 12, 183. Contreras-Ropero, J.E.; Ruiz-Roa, S.L.; García-Martínez, J.B.; Urbina-Suarez, N.A.; López-Barrera, G.L.; Barajas-Solano, A.F.; Zuorro, A. A Simulation Analysis of an Influenza Vaccine Production Plant in Areas of High Humanitarian Flow. A Preliminary Study for the Region of Norte de Santander (Colombia). Appl. Sci. 2022, 12, 183.

Journal reference: Appl. Sci. 2021, 12, 183
DOI: 10.3390/app12010183

Abstract

The production of vaccines of biological origin presents a tremendous challenge for researchers. In this context, animal cell cultures are an excellent alternative for the isolation and production of biologicals against several viruses since they have an affinity with viruses and a great capacity for their replicability. Different variables have been studied to know the system's ideal parameters, allowing it to obtain profitable and competitive products. Consequently, this work focuses its efforts on evaluating an alternative for producing an anti-influenza biological from MDCK cells using SuperPro Designer v8.0 software. The process uses the DMEN culture medium supplemented with nutrients as raw material for cell development; the MDCK cells were obtained from a potential scale-up with a final working volume of 500 L, four days of residence time, inoculum volume of 10%, and continuous working mode with up to a total of 7400 h/Yr of work. The scheme has the necessary equipment for the vaccine's production, infection, and manufacture with yields of up to 416,698 units/h. In addition, it was estimated to be economically viable to produce recombinant vaccines with competitive prices of up to 0.31 USD/unit.

Keywords

Modeling process; SuperPro Designer®; Cell Culture; Public health; Developing countries

Subject

ENGINEERING, Biomedical & Chemical Engineering

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