Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process

Version 1 : Received: 16 September 2021 / Approved: 17 September 2021 / Online: 17 September 2021 (10:11:15 CEST)

How to cite: Sánchez-Santamaría, B.; Mederos, B.; Cornejo-Monroy, D.; Molina-Arredondo, R.D.; Castaño, V. Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process. Preprints 2021, 2021090303 (doi: 10.20944/preprints202109.0303.v1). Sánchez-Santamaría, B.; Mederos, B.; Cornejo-Monroy, D.; Molina-Arredondo, R.D.; Castaño, V. Estimation of the Lifespan Distribution of Gold Nanoparticles Stabilized with Lipoic Acid by Accelerated Degradation Tests and Wiener Process. Preprints 2021, 2021090303 (doi: 10.20944/preprints202109.0303.v1).

Abstract

Accelerated degradation tests (ADT) are widely used in the manufacturing industry to obtain information on the reliability of components and materials, through degrading the lifespan of the product by applying an acceleration factor which causes damage to the material. The main objective is to obtain fast information which is modeled to estimate the characteristics of the material life under normal conditions of use and to save time and expenses. The purpose of this work is to estimate the lifespan distribution of gold nanoparticles stabilized with lipoic acid ([email protected]) through accelerated degradation tests applying sodium chloride (NaCl) as an acceleration factor. For this, the synthesis of [email protected] was carried out, a constant stress ADT (CSADT) was applied, and the non-linear Wiener process was proposed with random effects, error measures and different covariability for the adjustment of the degradation signals. The information obtained with the test and analysis allows us to obtain the life distribution in [email protected], the results make possible to determine the guaranteed time for a possible commercialization and successful application based on the stability of the material. In addition, for the evaluation and selection of the model, the Akaike and Bootstraping criteria were used.

Keywords

accelerated degradation tests; gold nanoparticles; life distribution; Wiener process

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