Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Review and Meta-Analysis of the Evidence for Choosing Between Specific Pyrethroids for Programmatic Purposes.

Natalie Lissenden
ORCID logo ,
Mara Kont
,
John Essandoh
,
Hanafy M Ismail
ORCID logo ,
Thomas S Churcher
,
Ben Lambert
,
Audrey Lenhart
,
Philip J McCall
ORCID logo ,
Catherine L Moyes
,
Mark J I Paine
,
Giorgio Praulins
,
David Weetman
,
Rosemary S Lees
* ORCID logo
Version 1 : Received: 5 August 2021 / Approved: 6 August 2021 / Online: 6 August 2021 (11:19:25 CEST)

A peer-reviewed article of this Preprint also exists.

Lissenden, N.; Kont, M.D.; Essandoh, J.; Ismail, H.M.; Churcher, T.S.; Lambert, B.; Lenhart, A.; McCall, P.J.; Moyes, C.L.; Paine, M.J.I.; Praulins, G.; Weetman, D.; Lees, R.S. Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes. Insects 2021, 12, 826. Lissenden, N.; Kont, M.D.; Essandoh, J.; Ismail, H.M.; Churcher, T.S.; Lambert, B.; Lenhart, A.; McCall, P.J.; Moyes, C.L.; Paine, M.J.I.; Praulins, G.; Weetman, D.; Lees, R.S. Review and Meta-Analysis of the Evidence for Choosing between Specific Pyrethroids for Programmatic Purposes. Insects 2021, 12, 826.

Abstract

Pyrethroid resistance is widespread in malaria vectors. However, differential mortality in discriminating dose assays to different pyrethroids is often observed in wild populations. When this occurs, it is unclear if this differential mortality should be interpreted as an indication of differential levels of susceptibility within the pyrethroid class, and if so, if countries should consider selecting one specific pyrethroid for programmatic use over another. A review of evidence from molecular studies, resistance testing with laboratory colonies and wild populations, and mosquito behavioural assays was conducted to answer these questions. Evidence suggests that in areas where pyrethroid resistance exists, different results in insecticide susceptibility assays with specific pyrethroids currently in common use (deltamethrin, permethrin, α-cypermethrin and λ-cyhalothrin) are not necessarily indicative of an operationally relevant difference in potential performance. Consequently, it is not advisable to use rotation between these pyrethroids as an insecticide resistance management strategy. Less commonly used pyrethroids (bifenthrin and etofenprox) may have sufficiently different modes of action, though further work would be needed to examine how this may apply to insecticide resistance management.

Keywords

Pyrethroid; pyrethroid resistance; insecticide resistance; insecticide resistance management; vector control; malaria; malaria control; mosquito; Anopheles

Subject

Biology and Life Sciences, Insect Science

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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