Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Clearing Steatosis Prior to Liver Surgery for Colorectal Metastasis: A Narrative Review and Case Illustration

Version 1 : Received: 4 August 2021 / Approved: 5 August 2021 / Online: 5 August 2021 (14:55:25 CEST)

How to cite: Peloso, A.; Tihy, M.; Rubbia-Brandt, L.; Toso, C. Clearing Steatosis Prior to Liver Surgery for Colorectal Metastasis: A Narrative Review and Case Illustration. Preprints 2021, 2021080147 (doi: 10.20944/preprints202108.0147.v1). Peloso, A.; Tihy, M.; Rubbia-Brandt, L.; Toso, C. Clearing Steatosis Prior to Liver Surgery for Colorectal Metastasis: A Narrative Review and Case Illustration. Preprints 2021, 2021080147 (doi: 10.20944/preprints202108.0147.v1).

Abstract

Over the recent years, non-alcoholic fatty liver disease (NAFLD) has become the most common liver disorder in the developed world, accounting for 20% to 46% of liver abnormalities. Steatosis is the hallmark of NAFLD and is recognized as an important risk factor for complication and death after general surgery, and even more so after liver resection. Similarly, liver steatosis also impacts the safety of live liver donation and transplantation. We aim to review surgical outcomes after liver resection for colorectal-metastases in patients with steatosis, and discuss the most common pre-operative strategies to reduce steatosis. Finally, as illustration, we report the favourable effect of a low-caloric, hyper-protein diet during a two-stage liver resection for colorectal metastases in a patient with severe steatosis.

Keywords

metabolic syndrome; colorectal cancer; nonalcoholic fatty liver disease; liver surgery; hepatic resection; fatty liver; nutrition; protein

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