Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Entropy and Entropic Forces to Model Biological Fluids

Version 1 : Received: 12 July 2021 / Approved: 13 July 2021 / Online: 13 July 2021 (14:16:17 CEST)

How to cite: Gutierrez, R.M.; Shubeita, G.T.; Murade, C.U.; Guo, J. Entropy and Entropic Forces to Model Biological Fluids. Preprints 2021, 2021070309 (doi: 10.20944/preprints202107.0309.v1). Gutierrez, R.M.; Shubeita, G.T.; Murade, C.U.; Guo, J. Entropy and Entropic Forces to Model Biological Fluids. Preprints 2021, 2021070309 (doi: 10.20944/preprints202107.0309.v1).

Abstract

Living cells are complex systems that may be characterized by fluids crowded by hundreds of different elements in particular by a high density of polymers; they are an excellent and challenging laboratory to study exotic emerging physical phenomena where entropic forces emerge from organization processes of many-body interactions. The competition between microscopic and entropic forces may generate complex behaviors like phase transitions that living cells may use to accomplish their functions. In the era of the big data, when biological information abounds but general principles and precise understanding of the microscopic interactions scarce, the entropy methods may offer significant information. In this work we develop a model where the thermodynamic equilibrium results from the competition between an effective electrostatic shortrange interaction and the entropic forces emerging in a fluid crowded by different size polymers. The target audience for this article are interdisciplinary researchers in complex systems, particularly in thermodynamics and biophysics modeling.

Subject Areas

entropic forces; biological fluids; crowding; polymer’s configurations

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