Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

Version 1 : Received: 7 July 2021 / Approved: 8 July 2021 / Online: 8 July 2021 (10:59:08 CEST)

How to cite: Herlan, C.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids. Preprints 2021, 2021070196 (doi: 10.20944/preprints202107.0196.v1). Herlan, C.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids. Preprints 2021, 2021070196 (doi: 10.20944/preprints202107.0196.v1).

Abstract

The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

Subject Areas

peptidomimetics; tetramers; macrocycles; spatial structure.

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