Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

Claudine Herlan; Anna Sonnefeld; Thomas Gloge; Julian Brückel; Luisa Schlee; Claudia Muhle-Goll; Martin Nieger; Stefan Bräse

doi:10.20944/preprints202107.0196.v1

A peer-reviewed article of this Preprint also exists.

Herlan, C.N.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.C.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids. Molecules 2021, 26, 4548. Herlan, C.N.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.C.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids. Molecules 2021, 26, 4548.

Abstract

The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

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Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

Abstract

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