Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Macrocyclic Tetramers – Structural Investigation of Peptide-Peptoid Hybrids

Version 1 : Received: 7 July 2021 / Approved: 8 July 2021 / Online: 8 July 2021 (10:59:08 CEST)

A peer-reviewed article of this Preprint also exists.

Herlan, C.N.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.C.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids. Molecules 2021, 26, 4548. Herlan, C.N.; Sonnefeld, A.; Gloge, T.; Brückel, J.; Schlee, L.C.; Muhle-Goll, C.; Nieger, M.; Bräse, S. Macrocyclic Tetramers—Structural Investigation of Peptide-Peptoid Hybrids. Molecules 2021, 26, 4548.

Journal reference: Molecules 2021, 26, 4548
DOI: 10.3390/molecules26154548

Abstract

The determination of the three-dimensional structure is a key step for the identification of new targets as well as the rational design of bioactive compounds. Herein, we report the synthesis and the structural elucidation of novel tetrameric macrocycles. Measurements were taken in solid and solution states with the help of X-ray scattering and NMR spectroscopy. The investigations made will help to find diverse applications for this new, promising compound class.

Keywords

peptidomimetics; tetramers; macrocycles; spatial structure.

Subject

CHEMISTRY, Analytical Chemistry

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.