Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

AT Homopolymer Strings as a Motif for Self-Recognition and Repair of Genomes in Salmonella enterica Subspecies I

Jean Guard
* ORCID logo ,
Adam R Rivers
,
Justin N Vaughn
,
Michael J Rothrock, Jr
,
Adelumola Oladeinde
ORCID logo ,
Devendra H Shah
ORCID logo
Version 1 : Received: 13 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (07:43:34 CEST)
Version 2 : Received: 27 August 2021 / Approved: 31 August 2021 / Online: 31 August 2021 (12:47:33 CEST)

A peer-reviewed article of this Preprint also exists.

Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms 2021, 9, 2075. Guard, J.; Rivers, A.R.; Vaughn, J.N.; Rothrock, M.J., Jr.; Oladeinde, A.H.; Shah, D.H. AT Homopolymer Strings in Salmonella enterica Subspecies I Contribute to Speciation and Serovar Diversity. Microorganisms 2021, 9, 2075.

Journal reference: Microorganisms 2021, 9, 2075
DOI: 10.3390/microorganisms9102075

Abstract

Adenine and thymine homopolymer strings of at least 8 nucleotides (AT 8+mers) were charac-terized in Salmonella enterica subspecies I and other Eubacteria. Incidence of the motif differed between Eubacteria but not between Salmonella enterica serotypes. Of 481 AT 8+mers loci in serovars Typhimurium, Enteritidis, and Gallinarum, 35 (12.3%) had mutations. We propose that the AT 8+mer motif identifies genomes with optimal gene content and provides self-recognition that facilitates efficient genome repair. A theory that genome regeneration accounts for both serovar diversity and persistence of predominant Salmonella serovars associated provides a new framework for investigating root causes of foodborne illness.

Keywords

Salmonella enterica; food safety; genome; theory; single nucleotide polymorphisms; recombination; serotype

Subject

BIOLOGY, Anatomy & Morphology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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