AT Homopolymer Strings as a Motif for Self-Recognition and Repair of Genomes in Salmonella enterica Subspecies I

Jean Guard; Adam R Rivers; Justin N Vaughn; Michael J Rothrock, Jr; Adelumola Oladeinde; Devendra H Shah

doi:10.20944/preprints202106.0384.v1

Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 13 June 2021 / Approved: 15 June 2021 / Online: 15 June 2021 (07:43:34 CEST)

Adenine and thymine homopolymer strings of at least 8 nucleotides (AT 8+mers) were charac-terized in Salmonella enterica subspecies I and other Eubacteria. Incidence of the motif differed between Eubacteria but not between Salmonella enterica serotypes. Of 481 AT 8+mers loci in serovars Typhimurium, Enteritidis, and Gallinarum, 35 (12.3%) had mutations. We propose that the AT 8+mer motif identifies genomes with optimal gene content and provides self-recognition that facilitates efficient genome repair. A theory that genome regeneration accounts for both serovar diversity and persistence of predominant Salmonella serovars associated provides a new framework for investigating root causes of foodborne illness.

Salmonella enterica; food safety; genome; theory; single nucleotide polymorphisms; recombination; serotype

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AT Homopolymer Strings as a Motif for Self-Recognition and Repair of Genomes in Salmonella enterica Subspecies I

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