Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-enhanced MRI and Comparison with Histologic Collagen Content

Kiyohisa Kamimura
* ORCID logo ,
Masanori Nakajo
,
Manisha Bohara
,
Daigo Nagano
,
Yoshihiko Fukukura
,
Shingo Fujio
,
Tomoko Takajo
,
Kazuhiro Tabata
,
Takashi Iwanaga
,
Hiroshi Imai
,
Marcel Dominik Nickel
,
Takashi Yoshiura
Version 1 : Received: 5 June 2021 / Approved: 7 June 2021 / Online: 7 June 2021 (13:25:15 CEST)

How to cite: Kamimura, K.; Nakajo, M.; Bohara, M.; Nagano, D.; Fukukura, Y.; Fujio, S.; Takajo, T.; Tabata, K.; Iwanaga, T.; Imai, H.; Nickel, M.D.; Yoshiura, T. Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-enhanced MRI and Comparison with Histologic Collagen Content. Preprints 2021, 2021060185. https://doi.org/10.20944/preprints202106.0185.v1 Kamimura, K.; Nakajo, M.; Bohara, M.; Nagano, D.; Fukukura, Y.; Fujio, S.; Takajo, T.; Tabata, K.; Iwanaga, T.; Imai, H.; Nickel, M.D.; Yoshiura, T. Consistency of Pituitary Adenoma: Prediction by Pharmacokinetic Dynamic Contrast-enhanced MRI and Comparison with Histologic Collagen Content. Preprints 2021, 2021060185. https://doi.org/10.20944/preprints202106.0185.v1

Abstract

Prediction of tumor consistency is valuable for planning transsphenoidal surgery for pituitary adenoma. A prospective study was conducted involving 49 participants with pituitary adenoma to determine whether quantitative pharmacokinetic analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is useful for predicting consistency of adenoma. Pharmacokinetic parameters in the adenomas including volume of extravascular extracellular space (EES) per unit volume of tissue (ve), blood plasma volume per unit volume of tissue (vp), volume transfer constant between blood plasma and EES (Ktrans), and rate constant between EES and blood plasma (kep) were obtained. The pharmacokinetic parameters and the histologic percentage of collagen content (PCC) were compared between soft and hard adenomas using Mann–Whitney U test. Pearson’s correla-tion coefficient was used to correlate pharmacokinetic parameters with PCC. Hard adenomas showed significantly higher PCC (44.08 ± 15.14% vs. 6.62 ± 3.47%, p < 0.01), ve (0.332 ± 0.124% vs. 0.221 ± 0.104%, p = 0.02), and Ktrans (0.775 ± 0.401/min vs. 0.601 ± 0.612/min, p = 0.02) than soft adenomas. Moreover, a significant positive correlation was found between ve and PCC (r = 0.601, p < 0.01). The ve derived using DCE-MRI may have predictive value for consistency of pituitary adenoma.

Keywords

pituitary adenoma; consistency; magnetic resonance imaging; pharmacokinetic analysis; collagen.

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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