Version 1
: Received: 4 June 2021 / Approved: 7 June 2021 / Online: 7 June 2021 (09:29:06 CEST)
How to cite:
Meng, X.; Gao, J.Z.; Gomendoza, S.M.T.; Li, J.; Yang, S. Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints2021, 2021060158. https://doi.org/10.20944/preprints202106.0158.v1
Meng, X.; Gao, J.Z.; Gomendoza, S.M.T.; Li, J.; Yang, S. Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints 2021, 2021060158. https://doi.org/10.20944/preprints202106.0158.v1
Meng, X.; Gao, J.Z.; Gomendoza, S.M.T.; Li, J.; Yang, S. Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints2021, 2021060158. https://doi.org/10.20944/preprints202106.0158.v1
APA Style
Meng, X., Gao, J.Z., Gomendoza, S.M.T., Li, J., & Yang, S. (2021). Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints. https://doi.org/10.20944/preprints202106.0158.v1
Chicago/Turabian Style
Meng, X., John Li and Shujie Yang. 2021 "Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations" Preprints. https://doi.org/10.20944/preprints202106.0158.v1
Abstract
p53 is among the most frequently mutated tumor suppressor genes given its prevalence in >50% of all human cancers, including high grade serous endometrial cancers and ovarian cancers. In addition to loss of tumor suppression function, many mutated p53 (Mutp53) proteins acquire gain-of-function (GOF) activities as oncogenes to promote cancer progression, which manifest through aberrant expression of p53. As we have come to see, statins induce CHIP-mediated degradation of mutp53 by blocking the interaction between mutp53 and DNAJA1. Therefore, targeting critical downstream pathways of mutp53 provides an alternative strategy for treating cancers expressing mutp53. In this review, we summarize recent advances with Wee1 inhibitors and mevalonate pathway inhibitors, particularly statins, regarding their use in gynecological cancers with p53 mutations.
Keywords
p53; Wee1; AZD1775; statins
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
