Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations

Version 1 : Received: 4 June 2021 / Approved: 7 June 2021 / Online: 7 June 2021 (09:29:06 CEST)

How to cite: Meng, X.; Gao, J.Z.; Gomendoza, S.M.T.; Li, J.; Yang, S. Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints 2021, 2021060158 (doi: 10.20944/preprints202106.0158.v1). Meng, X.; Gao, J.Z.; Gomendoza, S.M.T.; Li, J.; Yang, S. Recent Advances of Wee1 Inhibitors and Statins in Gynecologic Cancers with p53 Mutations. Preprints 2021, 2021060158 (doi: 10.20944/preprints202106.0158.v1).

Abstract

p53 is among the most frequently mutated tumor suppressor genes given its prevalence in >50% of all human cancers, including high grade serous endometrial cancers and ovarian cancers. In addition to loss of tumor suppression function, many mutated p53 (Mutp53) proteins acquire gain-of-function (GOF) activities as oncogenes to promote cancer progression, which manifest through aberrant expression of p53. As we have come to see, statins induce CHIP-mediated degradation of mutp53 by blocking the interaction between mutp53 and DNAJA1. Therefore, targeting critical downstream pathways of mutp53 provides an alternative strategy for treating cancers expressing mutp53. In this review, we summarize recent advances with Wee1 inhibitors and mevalonate pathway inhibitors, particularly statins, regarding their use in gynecological cancers with p53 mutations.

Keywords

p53; Wee1; AZD1775; statins

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.