Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Histone Methylation in Maintenance of Genome Integrity

Version 1 : Received: 17 May 2021 / Approved: 20 May 2021 / Online: 20 May 2021 (10:26:07 CEST)

A peer-reviewed article of this Preprint also exists.

Mushtaq, A.; Mir, U.S.; Hunt, C.R.; Pandita, S.; Tantray, W.W.; Bhat, A.; Pandita, R.K.; Altaf, M.; Pandita, T.K. Role of Histone Methylation in Maintenance of Genome Integrity. Genes 2021, 12, 1000. Mushtaq, A.; Mir, U.S.; Hunt, C.R.; Pandita, S.; Tantray, W.W.; Bhat, A.; Pandita, R.K.; Altaf, M.; Pandita, T.K. Role of Histone Methylation in Maintenance of Genome Integrity. Genes 2021, 12, 1000.

Journal reference: Genes 2021, 12, 1000
DOI: 10.3390/genes12071000

Abstract

Packaging of the eukaryotic DNA genome with histone and other proteins forms a chromatin structure that regulates the outcome of all DNA mediated processes. The cellular pathways that ensure genomic stability detect and repair DNA damage through mechanisms which are critically dependent upon chromatin structures established by histones and, particularly, transient histone post-translational modifications . Though subject to a range of modifications, histone methylation is especially crucial for DNA damage repair as the methylated histones often form platforms for subsequent repair protein binding at damaged sites. In this review, we highlight and discuss how histone methylation impacts the maintenance of genome integrity through effects related to DNA repair and repair pathway choice.

Keywords

Histone Methylation, DNA repair, homologous recombination, Non homologous end joining

Subject

BIOLOGY, Anatomy & Morphology

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