Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

From Mechanisms to Functions: The Role of Synchronization in the Intrahippocampal Circuits

Version 1 : Received: 14 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (15:48:27 CEST)

How to cite: Mysin, I.; Shubina, L. From Mechanisms to Functions: The Role of Synchronization in the Intrahippocampal Circuits. Preprints 2021, 2021050350 (doi: 10.20944/preprints202105.0350.v1). Mysin, I.; Shubina, L. From Mechanisms to Functions: The Role of Synchronization in the Intrahippocampal Circuits. Preprints 2021, 2021050350 (doi: 10.20944/preprints202105.0350.v1).

Abstract

The brain rhythms are essential for information processing in neuronal networks. Oscillations recorded in different brain regions can be synchronized and have a constant phase difference, i.e. be coherent. Coherence between local field potential (LFP) signals from different regions in the brain may be correlated with the performance of cognitive tasks, from which it is concluded that these regions of the brain are involved in the task performance together. In this review, we discuss why coherence occurs and how it is coupled to the information transfer between different regions of the hippocampal formation. Coherence in theta and gamma frequency ranges is described since these rhythms are most pronounced during the hippocampus-dependent attention and memory. We review in vivo studies of interactions between different regions of the hippocampal formation in theta and gamma frequency bands. The kay provisions of the review: 1) coherence emerges from synchronous postsynaptic currents in principal neurons, occurring as a result of synchronization of neuronal spike activity; 2) synchronization of neuronal spike patterns in two regions of the hippocampal formation can be realised through induction or resonance; 3) coherence at a specific time point reflects the transfer of information between regions of the hippocampal formation, in particular, gamma coherence reflects the coupling of active neuronal ensembles. Overall, coherence is not an epiphenomenon, but an important physiological process that has certain generation mechanisms and performs important functions in information processing and transmission across the brain regions.

Keywords

theta rhythm; gamma rhythm; coherence; local field potential; hippocampus

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