Working Paper Review Version 1 This version is not peer-reviewed

How Physical Factors Coordinate Virus Infection – a Perspective from Mechanobiology

Version 1 : Received: 13 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (14:48:03 CEST)

How to cite: Liu, W.; Tang, D.; Xu, X.; Liu, Y.; Jiu, Y. How Physical Factors Coordinate Virus Infection – a Perspective from Mechanobiology. Preprints 2021, 2021050343 Liu, W.; Tang, D.; Xu, X.; Liu, Y.; Jiu, Y. How Physical Factors Coordinate Virus Infection – a Perspective from Mechanobiology. Preprints 2021, 2021050343

Abstract

Pandemics caused by viruses have threatened lives of thousands of people. Viral infection is a complex and diverse process, and substantial studies have been complemented in understanding the biochemical and molecular interactions between viruses and hosts. However, the physical microenvironment where infections implement is often less carefully considered, and the role of mechanobiology in viral infection remains elusive. Mechanobiology focuses on sensation, transduction and response to intracellular and extracellular physical factors by tissues, cells and extracellular matrix. The intracellular cytoskeleton and mechanosensors have been proved to be extensively involved in virus life cycle. Furthermore, innovative methods in vivo and in vitro are being utilized to elucidate how extracellular factors including stiffness, forces and topography in regulating viral infection. Our current review covers how physical factors from different sources coordinate virus infection. We further discuss how this knowledge can be harnessed in future research on cross-fields of mechanobiology and virology.

Subject Areas

virus infection; mechanobiology; cytoskeleton; mechanosensors; shear stress; tensile or compressive forces; topography; organ-on-a-chip

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