Submitted:
08 May 2021
Posted:
10 May 2021
Read the latest preprint version here
Abstract
The effect of aqueous extracts of the biomass of the adult beetle Ulomoides dermestoides on the delayed effects of defoliant paraquat causing parkinsonism in experimental mice was evaluated. The motor activity of the animals was analyzed in behavioral tests using a rotarod and a vertical pole. The number of tyrosine hydroxylase-immunopositive neurons in the ventral part of the substantia nigra of the midbrain of experimental and control mice were studied by immunohistochemistry. In the model in vitro system with SH-SY5Y–human neuroblastoma, the effect of the extracts on cell proliferation was examined in the absence and in the presence of the neurotoxin MPP+. The isolation of biologically active substances from raw biomass using cavitation effects made it possible to obtain extracts with protective properties in the model of an early stage of Parkinson's disease used.
Keywords:
Parkinson’s disease
; neurotoxic model
; early stage
; biologically active substances from insects
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