Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Preventive Activity of the Extract of the Darkling Beetle Ulomoides Dermestoides in the Diet of C57Bl/6JSTO Mice in a Neurotoxic Model of Parkinson's Disease

Version 1 : Received: 8 May 2021 / Approved: 10 May 2021 / Online: 10 May 2021 (13:47:23 CEST)
Version 2 : Received: 13 May 2021 / Approved: 14 May 2021 / Online: 14 May 2021 (10:58:45 CEST)

How to cite: Kovalzon, V.M.; Ambaryan, A.V.; Revishchin, A.V.; Rybalkina, E.Y.; Bastrakov, A.I.; Ushakova, N.A. Preventive Activity of the Extract of the Darkling Beetle Ulomoides Dermestoides in the Diet of C57Bl/6JSTO Mice in a Neurotoxic Model of Parkinson's Disease. Preprints 2021, 2021050190 (doi: 10.20944/preprints202105.0190.v1). Kovalzon, V.M.; Ambaryan, A.V.; Revishchin, A.V.; Rybalkina, E.Y.; Bastrakov, A.I.; Ushakova, N.A. Preventive Activity of the Extract of the Darkling Beetle Ulomoides Dermestoides in the Diet of C57Bl/6JSTO Mice in a Neurotoxic Model of Parkinson's Disease. Preprints 2021, 2021050190 (doi: 10.20944/preprints202105.0190.v1).

Abstract

The effect of aqueous extracts of the biomass of the adult beetle Ulomoides dermestoides on the delayed effects of defoliant paraquat causing parkinsonism in experimental mice was evaluated. The motor activity of the animals was analyzed in behavioral tests using a rotarod and a vertical pole. The number of tyrosine hydroxylase-immunopositive neurons in the ventral part of the substantia nigra of the midbrain of experimental and control mice were studied by immunohistochemistry. In the model in vitro system with SH-SY5Y–human neuroblastoma, the effect of the extracts on cell proliferation was examined in the absence and in the presence of the neurotoxin MPP+. The isolation of biologically active substances from raw biomass using cavitation effects made it possible to obtain extracts with protective properties in the model of an early stage of Parkinson's disease used.

Subject Areas

Parkinson’s disease; neurotoxic model; early stage; biologically active substances from insects

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