Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Changes in Overall Survival Over Time for Patients With de Novo Metastatic Breast Cancer

Version 1 : Received: 1 May 2021 / Approved: 6 May 2021 / Online: 6 May 2021 (14:56:00 CEST)

A peer-reviewed article of this Preprint also exists.

Iwase, T.; Shrimanker, T.V.; Rodriguez-Bautista, R.; Sahin, O.; James, A.; Wu, J.; Shen, Y.; Ueno, N.T. Changes in Overall Survival over Time for Patients with de novo Metastatic Breast Cancer. Cancers 2021, 13, 2650. Iwase, T.; Shrimanker, T.V.; Rodriguez-Bautista, R.; Sahin, O.; James, A.; Wu, J.; Shen, Y.; Ueno, N.T. Changes in Overall Survival over Time for Patients with de novo Metastatic Breast Cancer. Cancers 2021, 13, 2650.

Journal reference: Cancers 2021, 13, 2650
DOI: 10.3390/cancers13112650

Abstract

The purpose of this study was to determine the change in overall survival (OS) for patients with de novo metastatic breast cancer (dnMBC) over time. We conducted a retrospective cohort study with 1981 patients with dnMBC diagnosed between January 1995 and December 2017 at The University of Texas MD Anderson Cancer Center. OS was measured from the date of diagnosis of dnMBC. OS was compared between patients diagnosed during different time periods: 5-year periods and periods defined according to when key agents were approved for clinical use. The median OS was 3.4 years. The 5- and 10-year OS rates improved over time across both types of time periods. A subgroup analysis showed that OS improved significantly over time for the estrogen-receptor-positive/HER2-positive (ER+/HER2+) subtype, and exhibited a tendency toward improvement over time for the ER-negative (ER-)/HER2+ subtype. Median OS was significantly longer in patients with non-inflammatory breast cancer (P = .02) and in patients with ER+ disease, progesterone-receptor-positive disease, HER2+ disease, lower nuclear grade, locoregional therapy, and metastasis to a single organ (all P <.0001). These findings showed that OS at 5 and 10 years after diagnosis in patients with dnMBC improved over time. The significant improvements in OS over time for the ER+/HER2+ subtype and the tendency toward improvement for ER-/HER2+ subtype suggest the contribution of HER2-targeted therapy to survival.

Keywords

Breast neoplasms; neoplasm metastasis; inflammatory breast neoplasms; survival analysis

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