Working Paper Article Version 2 This version is not peer-reviewed

Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and [email protected]82

Version 1 : Received: 29 April 2021 / Approved: 3 May 2021 / Online: 3 May 2021 (08:57:39 CEST)
Version 2 : Received: 24 May 2021 / Approved: 26 May 2021 / Online: 26 May 2021 (14:19:39 CEST)

A peer-reviewed article of this Preprint also exists.

Mikheev, I.V.; Sozarukova, M.M.; Izmailov, D.Y.; Kareev, I.E.; Proskurnina, E.V.; Proskurnin, M.A. Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and [email protected]82. Int. J. Mol. Sci. 2021, 22, 5838. Mikheev, I.V.; Sozarukova, M.M.; Izmailov, D.Y.; Kareev, I.E.; Proskurnina, E.V.; Proskurnin, M.A. Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and [email protected] Int. J. Mol. Sci. 2021, 22, 5838.

Journal reference: Int. J. Mol. Sci. 2021, 22, 5838
DOI: 10.3390/ijms22115838

Abstract

The antioxidant potential (capacity and activity) of aqueous fullerene dispersions (AFD) of non-functionalized C60, C70, and [email protected]82 endofullerene (in micromolar concentration range) was estimated based on chemiluminescence measurements of the model of luminol and generation of organic radicals by 2,2’-azobis(2-amidinopropane) dihydrochloride (ABAP). The antioxidant capacity was estimated by the TRAP method, from the concentration of half-suppression, and from the suppression area in the initial period. All three approaches agree and show that the antioxidant capacity of AFDs increased in the row [email protected]82 < C70 < C60. Mathematical modeling of the long-term kinetics data was used for antioxidant activity estimation. The effect of C60 and C70 is found to be quenching of the excited product of luminol with ABAP-generated radical and not an actual antioxidant effect; quenching constants differ insignificantly. Apart from quenching with a similar constant, the AFD of [email protected]82 exhibits actual antioxidant action. The antioxidant activity in [email protected]82 is 300-fold higher than quenching constants.

Subject Areas

Fullerene; Endofullerene; Aqueous Fullerene Dispersion; Antioxidant Potential; Kinetic Chemiluminometry

Comments (1)

Comment 1
Received: 26 May 2021
Commenter: Ivan Mikheev
Commenter's Conflict of Interests: Author
Comment: Significant changes have been made to the
- a new title of the manuscript was introduced, including the specific objects of study fullerenes C60, C70, and [email protected]82;
- figures have been corrected, some of them have been made merged. Graphical abstract has been changed to clarify the main idea of this article;
- section deals with obtaining and characterization of aqueous dispersions of fullerenes were moved to supplementary material;
- the results section has been expanded and rearranged;
- novel references for manuscript and supplementary material have been added;
- the discussion section has been redesigned and written more clearly;
- abstract section has been improved and redesigned.
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