Mikheev, I.V.; Sozarukova, M.M.; Izmailov, D.Y.; Kareev, I.E.; Proskurnina, E.V.; Proskurnin, M.A. Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and [email protected]82. Int. J. Mol. Sci.2021, 22, 5838.
Mikheev, I.V.; Sozarukova, M.M.; Izmailov, D.Y.; Kareev, I.E.; Proskurnina, E.V.; Proskurnin, M.A. Antioxidant Potential of Aqueous Dispersions of Fullerenes C60, C70, and [email protected] Int. J. Mol. Sci. 2021, 22, 5838.
The antioxidant potential (capacity and activity) of aqueous fullerene dispersions (AFD) of non-functionalized C60, C70, and [email protected]82 endofullerene (in micromolar concentration range) was estimated based on chemiluminescence measurements of the model of luminol and generation of organic radicals by 2,2’-azobis(2-amidinopropane) dihydrochloride (ABAP). The antioxidant capacity was estimated by the TRAP method, from the concentration of half-suppression, and from the suppression area in the initial period. All three approaches agree and show that the antioxidant capacity of AFDs increased in the row [email protected]82 < C70 < C60. Mathematical modeling of the long-term kinetics data was used for antioxidant activity estimation. The effect of C60 and C70 is found to be quenching of the excited product of luminol with ABAP-generated radical and not an actual antioxidant effect; quenching constants differ insignificantly. Apart from quenching with a similar constant, the AFD of [email protected]82 exhibits actual antioxidant action. The antioxidant activity in [email protected]82 is 300-fold higher than quenching constants.
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