Preprint Review Version 3 Preserved in Portico This version is not peer-reviewed

Maternal Supply of Both Arachidonic and Docosahexaenoic Acids is Required for Optimal Neurodevelopment

Version 1 : Received: 25 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (12:48:22 CEST)
Version 2 : Received: 26 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (15:11:00 CEST)
Version 3 : Received: 14 June 2021 / Approved: 14 June 2021 / Online: 14 June 2021 (14:54:08 CEST)

How to cite: Basak, S.; Mallick, R.; Banerjee, A.; Pathak, S.; Duttaroy, A.K. Maternal Supply of Both Arachidonic and Docosahexaenoic Acids is Required for Optimal Neurodevelopment . Preprints 2021, 2021040665 (doi: 10.20944/preprints202104.0665.v3). Basak, S.; Mallick, R.; Banerjee, A.; Pathak, S.; Duttaroy, A.K. Maternal Supply of Both Arachidonic and Docosahexaenoic Acids is Required for Optimal Neurodevelopment . Preprints 2021, 2021040665 (doi: 10.20944/preprints202104.0665.v3).

Abstract

During the last trimester of gestation and for the first 18 months after birth, both docosahexaenoic acid,22:6n-3 (DHA) and arachidonic acid,20:4n-6 (ARA) are preferentially deposited within the cerebral cortex at a rapid rate. Although, the structural and functional roles of DHA in brain development are well investigated, similar roles of ARA are not well documented. The mode of action of these two fatty acids and their derivatives at different structural-functional roles and their levels in the gene expression and signaling pathways of the brain have been continuously emanating. In addition to DHA, importance of ARA has been much discussed in recent years for fetal and postnatal brain development and the maternal supply of ARA and DHA. These fatty acids are also involved in various brain developmental processes; however, their mechanistic cross talks are not clearly known yet. This review describes the importance of ARA, in addition to DHA to support the optimal brain development and growth and functional roles in the brain.

Keywords

Arachidonic acid, 20:4n-6; Brain; Docosahexaenoic acid, 22:6n-3; Fetus; Maternal diet; Cognitive; Infants; Neurodevelopment; Neurogenesis

Comments (1)

Comment 1
Received: 14 June 2021
Commenter: Asim K. Duttaroy
Commenter's Conflict of Interests: Author
Comment: This version is now accepted for publication in Nutrietnts.
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