Version 1
: Received: 25 April 2021 / Approved: 26 April 2021 / Online: 26 April 2021 (10:57:31 CEST)
How to cite:
Cherian, P.; Al-Khairi, I.; Jamal, M.; Al-Sabah, S.; Ali, H.; Dsouza, C.; Shawaf, E. A.; Al-Ali, W.; Al-khaledi, G.; Al-Mulla, F.; Abu-Farha, M.; Abubaker, J. Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity. Preprints2021, 2021040655. https://doi.org/10.20944/preprints202104.0655.v1
Cherian, P.; Al-Khairi, I.; Jamal, M.; Al-Sabah, S.; Ali, H.; Dsouza, C.; Shawaf, E. A.; Al-Ali, W.; Al-khaledi, G.; Al-Mulla, F.; Abu-Farha, M.; Abubaker, J. Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity. Preprints 2021, 2021040655. https://doi.org/10.20944/preprints202104.0655.v1
Cherian, P.; Al-Khairi, I.; Jamal, M.; Al-Sabah, S.; Ali, H.; Dsouza, C.; Shawaf, E. A.; Al-Ali, W.; Al-khaledi, G.; Al-Mulla, F.; Abu-Farha, M.; Abubaker, J. Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity. Preprints2021, 2021040655. https://doi.org/10.20944/preprints202104.0655.v1
APA Style
Cherian, P., Al-Khairi, I., Jamal, M., Al-Sabah, S., Ali, H., Dsouza, C., Shawaf, E. A., Al-Ali, W., Al-khaledi, G., Al-Mulla, F., Abu-Farha, M., & Abubaker, J. (2021). Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity. Preprints. https://doi.org/10.20944/preprints202104.0655.v1
Chicago/Turabian Style
Cherian, P., Mohamed Abu-Farha and Jehad Abubaker. 2021 "Association between Bone Biomarkers Osteoactivin and OPG with Plasma Levels of Irisin and Meteorin-like Protein in People with T2D and Obesity" Preprints. https://doi.org/10.20944/preprints202104.0655.v1
Abstract
The musculoskeletal system consisting of bones and muscles have been recognized as endocrine organs secreting hormones that are involved in regulating metabolic and inflammatory pathways. Obesity and type 2 diabetes (T2D) are associated with several musculoskeletal system complications. We hypothesized that an interaction exists between adipomyokines namely, irisin and METRNL, and various bone markers in individuals with obesity and T2D. A total of 228 individuals were enrolled in this study, including 124 non-diabetic and 104 T2D. A Multiplex assay was used to assess the level of various bone markers namely Osteoactivin, Syndecan, osteoprotegerin (OPG) and osteonectin/SPARC. Our data shows elevated levels of Osteoactivin, Syndecan, OPG and SPARC in T2D as compared to non-T2D individuals (p ≤ 0.05). Using Spearman’s correlation, irisin was positively correlated only with Osteoactivin and OPG (p < 0.05). Similarly, a positive association was observed between METRNL and Osteoactivin (p < 0.05). The strong positive association shown in our study between irisin, METRNL and various bone markers emphasises the strong interaction between these organs. This suggests that a dysregulation in the functional interaction between these molecules could play a possible role in the development of bone and muscle related complications that are associated with obesity and T2D.
Keywords
Meteorin-like hormone, irisin, adipomyokines, bone markers, Osteoactivin , Syndecan, OPG, Osteonectin, type 2 diabetes, obesity.
Subject
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.