Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Targeted Myocardial Restoration with Injectable Hydrogels - In Search of The Holy Grail in Regenerating Damaged Heart Tissue

Version 1 : Received: 21 April 2021 / Approved: 22 April 2021 / Online: 22 April 2021 (08:16:51 CEST)

How to cite: Sazzad, F.; Kuzemczak, M.; Loh, E.; Wu, W.; Kofidis, T. Targeted Myocardial Restoration with Injectable Hydrogels - In Search of The Holy Grail in Regenerating Damaged Heart Tissue. Preprints 2021, 2021040590 (doi: 10.20944/preprints202104.0590.v1). Sazzad, F.; Kuzemczak, M.; Loh, E.; Wu, W.; Kofidis, T. Targeted Myocardial Restoration with Injectable Hydrogels - In Search of The Holy Grail in Regenerating Damaged Heart Tissue. Preprints 2021, 2021040590 (doi: 10.20944/preprints202104.0590.v1).

Abstract

The peril of a 3-dimensional, robust and sustained myocardial restoration by means of Tissue Engineering is that it still remains a largely experimental approach. Prolific protocols have been developed and tested in small and large animals, but as clinical cardiac surgeons, we have not come to the privilege of utilizing any of them in our clinical practice. The question arises: why? The heart is a unique organ, anatomically and functionally. It is not an easy target to replicate with current techniques, or even to support its viability and function. Currently available therapies fail to reverse the loss of functional cardiac tissue, the fundamental pathology remains unaddressed and a heart transplantation is an ultima ratio treatment option. Owing to equivocal results of cell-based therapies, several strategies have been pursued to overcome limitations of the current treatment options. Preclinical data as well as first-in-human studies conducted to date have provided important insights into the understanding of injection-based approaches for myocardial restoration. In the light of the available data, injectable biomaterials suitable for transcatheteter delivery appear to have the highest translational potential,. This article presents a current state-of-the-art in the field of hydrogel-based myocardial restoration therapy.

Supplementary and Associated Material

Subject Areas

Hydrogel; Extracellular matrix hydrogels; Myocardial infarctions; Myocardial infarction therapy; Cardiac stem cell therapy; Tissue engineering; Cell-based therapy.

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