Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

COVID-19-Related Symptoms Among Cancer Patients and Healthcare Workers— First Results From the PAPESCO-19 Prospective Cohort Study

Version 1 : Received: 9 March 2021 / Approved: 10 March 2021 / Online: 10 March 2021 (16:17:48 CET)

How to cite: Zhou, K.; Blanc-Lapierre, A.; Seegers, V.; Boisdron-Celle, M.; Bigot, F.; Bourdon, M.; Mahammedi, H.; Lambert, A.; Campone, M.; Bellanger, M.; Raoul, J. COVID-19-Related Symptoms Among Cancer Patients and Healthcare Workers— First Results From the PAPESCO-19 Prospective Cohort Study . Preprints 2021, 2021030292 (doi: 10.20944/preprints202103.0292.v1). Zhou, K.; Blanc-Lapierre, A.; Seegers, V.; Boisdron-Celle, M.; Bigot, F.; Bourdon, M.; Mahammedi, H.; Lambert, A.; Campone, M.; Bellanger, M.; Raoul, J. COVID-19-Related Symptoms Among Cancer Patients and Healthcare Workers— First Results From the PAPESCO-19 Prospective Cohort Study . Preprints 2021, 2021030292 (doi: 10.20944/preprints202103.0292.v1).

Abstract

Background: Cancer patients may fail to distinguish COVID-19 symptoms such as anosmia, dysgeusia/ageusia, anorexia, headache, and fatigue, which are frequent after cancer treatments. We aimed to identify symptoms associated with COVID-19 and to assess the strength of their association in cancer and cancer-free populations. Methods: The prospective multicenter cohort study PAPESCO-19 included 878 cancer patients and 940 healthcare workers (HCWs) systematically tested for SARS-CoV-2-specific antibodies. Participants reported the results of routine screening RT-PCR and thirteen COVID-19 symptoms. Backward logistic regression identified the symptom combinations significantly associated with COVID-19. Results: COVID+ proportions were similar in patients (8%) and HCWs (9.5%, p=0.26), whereas symptomatic proportions were lower in patients (32%) than HCWs (52%, p<0.001). Anosmia, anorexia, fever, headache, and rhinorrhea together accurately discriminated (c-statistic=0.7027) COVID-19 cases in patients. Anosmia, dysgeusia/ageusia, muscle pain, intense fatigue, headache, and chest pain better discriminated (c-statistic=0.8830) COVID-19 cases in HCWs. Anosmia had the strongest association in patients (OR=7.48, 95% CI: 2.96–18.89) and HCWs (OR=5.71, 95% CI: 2.21–14.75). Conclusions: COVID-19 symptoms and their diagnostic performance differ in cancer patients and HCWs. Anosmia is associated with COVID-19 for patients, while dysgeusia/ageusia are not. Cancer patients deserve tailored preventive measures due to their particular COVID-19 symptom pattern.

Keywords

cancer; COVID-19; symptoms; healthcare workers; anosmia; dysgeusia; ageusia; France; serological test; RT-PCR

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