Version 1
: Received: 1 February 2021 / Approved: 3 February 2021 / Online: 3 February 2021 (14:59:49 CET)
Version 2
: Received: 23 March 2021 / Approved: 24 March 2021 / Online: 24 March 2021 (13:34:39 CET)
Chopra, S.; Myers, Z.; Sekhon, H.; Dufour, A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. Int. J. Mol. Sci.2021, 22, 2498.
Chopra, S.; Myers, Z.; Sekhon, H.; Dufour, A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. Int. J. Mol. Sci. 2021, 22, 2498.
Chopra, S.; Myers, Z.; Sekhon, H.; Dufour, A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. Int. J. Mol. Sci.2021, 22, 2498.
Chopra, S.; Myers, Z.; Sekhon, H.; Dufour, A. The Nerves to Conduct a Multiple Sclerosis Crime Investigation. Int. J. Mol. Sci. 2021, 22, 2498.
Abstract
Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative autoimmune disease characterized by aberrant infiltration of immune cells into the central nervous system (CNS) and by the loss of myelin. Sclerotic lesions and various inhibitory factors hamper remyelination processes within the CNS. MS patients typically experience gradual cognitive and physical disabilities as the disease progresses. The etiology of MS is still unclear and emerging evidence suggests that microbiome composition could play a much more significant role in disease pathogenesis than was initially thought. Initially believed to be isolated to the gut microenvironment, we now know that the microbiome plays a much broader role in various tissues and is essential in the development of the immune system. Here, we present some of the unexpected roles that the microbiome plays in MS and discuss approaches for the development of next-generation treatment strategies.
Keywords
Multiple sclerosis (MS); microbiome; bacteria; virus; immunity; central nervous system (CNS)
Subject
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
