Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration

Version 1 : Received: 21 January 2021 / Approved: 1 February 2021 / Online: 1 February 2021 (13:16:51 CET)

A peer-reviewed article of this Preprint also exists.

Clarke, T.L.; Johnson, R.L.; Simone, J.J.; Carlone, R.L. The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration. Int. J. Mol. Sci. 2021, 22, 2103. Clarke, T.L.; Johnson, R.L.; Simone, J.J.; Carlone, R.L. The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration. Int. J. Mol. Sci. 2021, 22, 2103.

Journal reference: Int. J. Mol. Sci. 2021, 22, 2103
DOI: 10.3390/ijms22042103

Abstract

Cannabis has long been used for its medicinal and psychoactive properties. With the relatively new adoption of formal medicinal cannabis regulations worldwide, the study of cannabinoids, both endogenous and exogenous, has similarly flourished in more recent decades. In particular, research investigating the role of cannabinoids in regeneration and neurodevelopment has yielded promising results in vertebrate models. However, regeneration-competent vertebrates are few, whereas a myriad of invertebrate species have been established as superb models for regeneration. As such, this review aims to provide a comprehensive summary of the endocannabinoid system, with a focus on current advances in the area of endocannabinoid system contributions to invertebrate neurodevelopment and regeneration.

Subject Areas

AEA; 2-AG; CB1; CB2; endocannabinoid; regeneration; neurodevelopment; invertebrate

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