Preprint Brief Report Version 1 Preserved in Portico This version is not peer-reviewed

High Frequency of Viral Co-Detections in Acute Bronchiolitis

Version 1 : Received: 20 January 2021 / Approved: 21 January 2021 / Online: 21 January 2021 (12:12:25 CET)

How to cite: PETAT, H.; GAJDOS, V.; ANGOULVANT, F.; VIDALAIN, P.; CORBET, S.; MARGUET, C.; BROUARD, J.; VABRET, A.; AR GOUILH, M. High Frequency of Viral Co-Detections in Acute Bronchiolitis. Preprints 2021, 2021010416 (doi: 10.20944/preprints202101.0416.v1). PETAT, H.; GAJDOS, V.; ANGOULVANT, F.; VIDALAIN, P.; CORBET, S.; MARGUET, C.; BROUARD, J.; VABRET, A.; AR GOUILH, M. High Frequency of Viral Co-Detections in Acute Bronchiolitis. Preprints 2021, 2021010416 (doi: 10.20944/preprints202101.0416.v1).

Abstract

Over two years (2012-2014), 719 nasopharyngeal samples were collected from 6 weeks to 12 months old infants presenting at emergency department with moderate to severe acute bronchiolitis. Viral testing was performed and we found 98% positive samples including 90% Respiratory Syncytial Virus, 34% Human Rhino Virus, and 55% viral co-detections with predominance of RSV/HRV co-infections (30%). Interestingly, we found that the risk of being infected by HRV is higher in the absence of RSV, suggesting interferences or exclusion mechanisms between these two viruses. Conversely, Coronavirus infection had no impact on the likelihood of co-infection involving HRV and RSV. Bronchiolitis is the leading cause of hospitalizations in infants before 12 months of age, and many questions about its role in the later chronic respiratory diseases (asthma and chronic obstructive pulmonary disease) do exist. Role of virus detection and burden of viral codetections need to be further explored, in order to understand the physiopathology of chronic respiratory diseases, a major public health issue.

Subject Areas

Respiratory Syncytial Virus, Molecular Diagnostic, Respiratory Viruses, Coronavirus, Bronchiolitis

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.