Version 1
: Received: 18 December 2020 / Approved: 22 December 2020 / Online: 22 December 2020 (10:51:11 CET)
Version 2
: Received: 15 January 2021 / Approved: 19 January 2021 / Online: 19 January 2021 (10:39:01 CET)
How to cite:
Reilly, I.; Burt, N.; Reilly, R.; Swami, A. An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints2020, 2020120555. https://doi.org/10.20944/preprints202012.0555.v1
Reilly, I.; Burt, N.; Reilly, R.; Swami, A. An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints 2020, 2020120555. https://doi.org/10.20944/preprints202012.0555.v1
Reilly, I.; Burt, N.; Reilly, R.; Swami, A. An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints2020, 2020120555. https://doi.org/10.20944/preprints202012.0555.v1
APA Style
Reilly, I., Burt, N., Reilly, R., & Swami, A. (2020). An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom. Preprints. https://doi.org/10.20944/preprints202012.0555.v1
Chicago/Turabian Style
Reilly, I., Rebecca Reilly and Ajay Swami. 2020 "An Update on the Chemistry, Pharmacology and Dose Calculations of Mepivacaine Hydrochloride for Podiatrists in the United Kingdom" Preprints. https://doi.org/10.20944/preprints202012.0555.v1
Abstract
Local anaesthetic agents suppress action potentials in excitable tissues by blocking voltage-gated sodium channels.In doing so they inhibit the depolarisation of nociceptive nerve fibres and so prevent the transmission of pain impulses.UK legislation allows HCPC-registered Podiatrists with POM-A annotation access to six local anaesthetic drugs and two of these with the addition of adrenaline.The use of local anaesthetia has transformed the treatment of nail pathology by Podiatrists.In the UK, the drug of choice in podiatric practice is 3% mepivacaine hydrochloride: it is a good choice of drug for digital anaesthesia.This paper will review the chemistry, pharmacology and dose calculation of mepivacaine, and challenge some of the orthodoxy over the rigid calculation of maximum safe dosages.
Keywords
Mepivacaine; Scandonest; local anaesthesia; pharmacology; maximum safe dose; podiatry
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received:
30 December 2020
The commenter has declared there is no conflict of interests.
Comment:
This is an invaluable resource that enhanced my LA module learning and is an excellent summary for a student LA exam revision. Podiatry-specifi and a much needed piece of work. So well-written that it has now taken up permanent residence in my LA folder! Thank you very much for this excellent publication, Ian!
Received:
2 January 2021
Commenter:
Ellie Evans
The commenter has declared there is no conflict of interests.
Comment:
Thanks Ian, this is great revision and cpd.
I’ve been through it twice and only seen a couple of “blips”:
Line 48 - I’m guessing anaesthetia is a word not a typo.
Line 79 - should “HMRs, 2012” be referenced?
Line 178 - “configuration f” is that a typo or a thing.
Line 236. - Maladad 2017 missing reference.
Line 526 - Buettner ref is not in alphabetical order.
I think that’s all.
I haven’t done any proof reading for ages, but I enjoyed that, it’s well written, and very relevant to our profession.
I haven’t made this a public comment because I’m unsure of the etiquette, if you want me to, I will post it for all to see.
Cheers
Ellie
The commenter has declared there is no conflict of interests.
Commenter: Ellie Evans
The commenter has declared there is no conflict of interests.
I’ve been through it twice and only seen a couple of “blips”:
Line 48 - I’m guessing anaesthetia is a word not a typo.
Line 79 - should “HMRs, 2012” be referenced?
Line 178 - “configuration f” is that a typo or a thing.
Line 236. - Maladad 2017 missing reference.
Line 526 - Buettner ref is not in alphabetical order.
I think that’s all.
I haven’t done any proof reading for ages, but I enjoyed that, it’s well written, and very relevant to our profession.
I haven’t made this a public comment because I’m unsure of the etiquette, if you want me to, I will post it for all to see.
Cheers
Ellie