Feline Infectious Peritonitis: Challenges and Promises of Coronavirus RNA Detection

Wadim Kapulkin; Pawel Kita

doi:10.20944/preprints202012.0337.v1

Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 11 December 2020 / Approved: 14 December 2020 / Online: 14 December 2020 (13:27:55 CET)

Our perspective article covers major findings concerning Feline Infectious Peritonitis (FIP) - a fatal coronaviral disease of cats. In the context of FIP pathogenesis, we outline disease signalment and focus on the challenges and promises of FIP invoking coronavirus RNA detection. In particular, we outline critical aspects of coronavirus RNA replication and biogenesis. We infer the replicative intermediates of feline coronavirus may constitute an underappreciated factor triggering the progression of the maladaptive immune response underlying FIP pathogenesis.

Feline Infectious Peritonitis (FIP); coronavirus; dsRNA

Biology and Life Sciences, Biochemistry and Molecular Biology

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Feline Infectious Peritonitis: Challenges and Promises of Coronavirus RNA Detection

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