Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Kluyveromyces marxianus: Current State of Omics Studies, Strain Improvement Strategy and Potential Industrial Implementation

Version 1 : Received: 6 November 2020 / Approved: 9 November 2020 / Online: 9 November 2020 (08:38:20 CET)

How to cite: Ha-Tran, D.M.; Nguyen, T.T.M.; Huang, C. Kluyveromyces marxianus: Current State of Omics Studies, Strain Improvement Strategy and Potential Industrial Implementation. Preprints 2020, 2020110264 (doi: 10.20944/preprints202011.0264.v1). Ha-Tran, D.M.; Nguyen, T.T.M.; Huang, C. Kluyveromyces marxianus: Current State of Omics Studies, Strain Improvement Strategy and Potential Industrial Implementation. Preprints 2020, 2020110264 (doi: 10.20944/preprints202011.0264.v1).

Abstract

Bioethanol has been considered as an excellent alternative to fossil fuels since it importantly contributes to the reduced consumption of the crude oil and to the alleviation of environmental pollution [1]. Up to now, the baker yeast Saccharomyces cerevisiae is the most common eukaryotic microorganism used in ethanol production. The inability of S. cerevisiae to grow on pentoses, however, hinders its effective growth on plant biomass hydrolysates, which contain large amounts of C5 and C12 sugars. The industrial-scale bioprocessing requires high temperature bioreactors, diverse carbon sources, and the high titer production of volatile compounds [2]. These criteria indicate that the search for alternative microbes possessing useful traits that meet the required standards of bioethanol production is necessary. Compared to other yeasts, Kluyveromyces marxianus has several advantages over the others, e.g. it could grow on a broad spectrum of substrates (C5, C6 and C12 sugars) [3], tolerate to high temperature, toxin [4,5] and a wide range of pH values [6], and produce volatile short-chain ester [2]. K. marxianus also shows a high ethanol production rate at high temperature and is a Crabtree-negative species [7]. These attributes make K. marxianus a promise as an industrial host for the biosynthesis of biofuels and other valuable chemicals.

Subject Areas

Bioethanol; Kluyveromyces marxianus; Omics technologies; gTME, and CRISPR-Cas9

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