Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Relationship between Dietary Fiber Intake and the Prognosis of Amyotrophic Lateral Sclerosis

Version 1 : Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (21:26:36 CEST)

A peer-reviewed article of this Preprint also exists.

Yu, H.; Kim, S.H.; Noh, M.-Y.; Lee, S.; Park, Y. Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea. Nutrients 2020, 12, 3420. Yu, H.; Kim, S.H.; Noh, M.-Y.; Lee, S.; Park, Y. Relationship between Dietary Fiber Intake and the Prognosis of Amytrophic Lateral Sclerosis in Korea. Nutrients 2020, 12, 3420.

Journal reference: Nutrients 2020, 12, 3420
DOI: 10.3390/nu12113420

Abstract

The gut microbiota has been suggested as an important factor in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS). This study aimed to investigate whether the intake of different kinds of dietary fiber was related to the disease progression rate (∆FS) and survival time. In total, 272 sporadic ALS patients diagnosed according to the revised EI Escorial criteria were recruited from March 2011 and were followed-up until the occurrence of events or the end of September 2020. The events included percutaneous endoscopic gastrostomy, tracheostomy, and death. Dietary fiber intake was calculated based on a 24-hour dietary recall and classified according to five major fiber-rich foods: vegetables, fruits, grains, legumes, and nuts/seeds. Among the total participants, the group with ∆FS values lower than the mean ∆FS (0.75) was noted in the highest tertiles of total and vegetable fiber intake. Participants with the highest tertile of vegetable fiber intake showed longer survival in the Kaplan–Meier analysis (p = 0.033). Notably, vegetable fiber intake was negatively correlated with pro-inflammatory cytokine (interleukin [IL]-1β, IL-6, and monocyte chemoattractant protein-1) levels in the cerebrospinal fluid. This study showed that vegetable fiber intake could influence the disease progression rate and survival time. Further clinical trials are needed to confirm whether dietary fiber supplementation improves the prognosis of ALS.

Subject Areas

Amyotrophic lateral sclerosis; dietary fiber; gut microbiota; prognosis; vegetable fiber

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.