Working Paper Review Version 1 This version is not peer-reviewed

Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents

Version 1 : Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (12:41:30 CEST)

How to cite: Pryimak, N.; Zaiachuk, M.; Kovalchuk, O.; Kovalchuk, I. Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints 2020, 2020100464 Pryimak, N.; Zaiachuk, M.; Kovalchuk, O.; Kovalchuk, I. Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints 2020, 2020100464

Abstract

Fibrosis is a condition characterized by thickening or/and scarring of various tissues. Fibrosis may develop in almost all tissues and organs, and it may be one of the leading causes of morbidity and mortality. It provokes excessive scarring that excels the usual wound healing response to trauma in numerous organs. Currently, very little can be done to prevent tissue fibrosis, and it is almost impossible to reverse it. Therefore, fibrosis is frequently associated with premature aging. In turn, aging is associated with more frequent incidences of fibrosis. Anti-inflammatory and immunosuppressive drugs are among the few treatments that may be efficient in preventing fibrosis. Numerous publications suggest that cannabinoids and extracts of Cannabis sativa have potent anti-inflammatory and anti-fibrogenic properties. In this review, we describe the types and mechanisms of fibrosis in various tissues and discuss various strategies for prevention and dealing with tissue fibrosis. We further introduce cannabinoids and their potential for the prevention and treatment of fibrosis, and therefore for extending healthy lifespan.

Subject Areas

fibrosis; medicinal plants; Cannabis sativa; cannabinoids; anti-fibrotic

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.