Version 1
: Received: 21 October 2020 / Approved: 22 October 2020 / Online: 22 October 2020 (12:41:30 CEST)
How to cite:
Pryimak, N.; Zaiachuk, M.; Kovalchuk, O.; Kovalchuk, I. Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints2020, 2020100464
Pryimak, N.; Zaiachuk, M.; Kovalchuk, O.; Kovalchuk, I. Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints 2020, 2020100464
Pryimak, N.; Zaiachuk, M.; Kovalchuk, O.; Kovalchuk, I. Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints2020, 2020100464
APA Style
Pryimak, N., Zaiachuk, M., Kovalchuk, O., & Kovalchuk, I. (2020). Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents. Preprints. https://doi.org/
Chicago/Turabian Style
Pryimak, N., Olga Kovalchuk and Igor Kovalchuk. 2020 "Tissue Fibrosis, Aging and the Potential Use of Cannabinoids as Anti-Fibrotic Agents" Preprints. https://doi.org/
Abstract
Fibrosis is a condition characterized by thickening or/and scarring of various tissues. Fibrosis may develop in almost all tissues and organs, and it may be one of the leading causes of morbidity and mortality. It provokes excessive scarring that excels the usual wound healing response to trauma in numerous organs. Currently, very little can be done to prevent tissue fibrosis, and it is almost impossible to reverse it. Therefore, fibrosis is frequently associated with premature aging. In turn, aging is associated with more frequent incidences of fibrosis. Anti-inflammatory and immunosuppressive drugs are among the few treatments that may be efficient in preventing fibrosis. Numerous publications suggest that cannabinoids and extracts of Cannabis sativa have potent anti-inflammatory and anti-fibrogenic properties. In this review, we describe the types and mechanisms of fibrosis in various tissues and discuss various strategies for prevention and dealing with tissue fibrosis. We further introduce cannabinoids and their potential for the prevention and treatment of fibrosis, and therefore for extending healthy lifespan.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
