Screening and Identification of New Biomarkers for the Control of Cervical Cancer

Mari Uyeda; Mahendran Subramanian

doi:10.20944/preprints202010.0220.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 11 October 2020 / Approved: 12 October 2020 / Online: 12 October 2020 (10:14:44 CEST)
Version 2 : Received: 1 December 2020 / Approved: 1 December 2020 / Online: 1 December 2020 (15:09:12 CET)
Version 3 : Received: 30 March 2021 / Approved: 30 March 2021 / Online: 30 March 2021 (09:32:47 CEST)

Cervical cancer (CC) is the most common cancer in women worldwide and is almost always associated with repeated infections by human papillomavirus (HPV). Screening by traditional tests associated with biomarker identification techniques for low- or high-grade injuries, are becoming increasingly important in diagnosis and prognosis, avoiding countless deaths. This article explores existing literature on the main serum biomarkers and the identification of biomarkers associated with the oncogenesis of HPV expression in the identification of pre-cancerous lesions and of CC for an effective treatment, with reduction of recurrence, as well as we explain strategies for the development of biomarkers based on DNA, proteins and other markers. We also describe how markers of chromosomal instability host DNA, promoting hypo- or hypermethylation of DNA, as well as polymorphisms and epigenetic events in the p53 gene. Finally, we discuss changes in gene expression using cDNA microarray techniques and changes in the expression of proteins and markers identified through mass spectrometry (MS).

Cervical cancer; Biomarkers; Human papillomavirus; Pap smear; cervical intraepithelial neoplasia

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Screening and Identification of New Biomarkers for the Control of Cervical Cancer

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