Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Screening and Identification of New Biomarkers for the Control of Cervical Cancer

Version 1 : Received: 11 October 2020 / Approved: 12 October 2020 / Online: 12 October 2020 (10:14:44 CEST)

How to cite: Uyeda, M.; Subramanian, M. Screening and Identification of New Biomarkers for the Control of Cervical Cancer. Preprints 2020, 2020100220 (doi: 10.20944/preprints202010.0220.v1). Uyeda, M.; Subramanian, M. Screening and Identification of New Biomarkers for the Control of Cervical Cancer. Preprints 2020, 2020100220 (doi: 10.20944/preprints202010.0220.v1).

Abstract

Cervical cancer (CC) is the most common cancer in women worldwide and is almost always associated with repeated infections by human papillomavirus (HPV). Screening by traditional tests associated with biomarker identification techniques for low- or high-grade injuries, are becoming increasingly important in diagnosis and prognosis, avoiding countless deaths. This article explores existing literature on the main serum biomarkers and the identification of biomarkers associated with the oncogenesis of HPV expression in the identification of pre-cancerous lesions and of CC for an effective treatment, with reduction of recurrence, as well as we explain strategies for the development of biomarkers based on DNA, proteins and other markers. We also describe how markers of chromosomal instability host DNA, promoting hypo- or hypermethylation of DNA, as well as polymorphisms and epigenetic events in the p53 gene. Finally, we discuss changes in gene expression using cDNA microarray techniques and changes in the expression of proteins and markers identified through mass spectrometry (MS).

Subject Areas

Cervical cancer; Biomarkers; Human papillomavirus; Pap smear; cervical intraepithelial neoplasia

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.