Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Potential Biomarkers for Cervical Cancer Screening and Treatment

Version 1 : Received: 11 October 2020 / Approved: 12 October 2020 / Online: 12 October 2020 (10:14:44 CEST)
Version 2 : Received: 1 December 2020 / Approved: 1 December 2020 / Online: 1 December 2020 (15:09:12 CET)
Version 3 : Received: 30 March 2021 / Approved: 30 March 2021 / Online: 30 March 2021 (09:32:47 CEST)

How to cite: Uyeda, M.; Subramanian, M. Potential Biomarkers for Cervical Cancer Screening and Treatment. Preprints 2020, 2020100220. Uyeda, M.; Subramanian, M. Potential Biomarkers for Cervical Cancer Screening and Treatment. Preprints 2020, 2020100220.


Cervical cancer (CC) is the most common cancer in women worldwide and is almost always associated with repeated infections by human papillomavirus (HPV). Screening by traditional tests combined with biomarker identification techniques for low- or high-grade injuries, are becoming increasingly important in diagnosis and prognosis, avoiding countless deaths. This article explores existing literature on the main serum biomarkers and the identification of biomarkers associated with the oncogenesis of HPV expression in the identification of pre-cancerous lesions and of CC for an effective treatment, with reduction of recurrence, as well as we explain strategies for the development of biomarkers based on DNA, proteins and other markers. We also describe how markers of chromosomal instability host DNA, promoting hypo- or hypermethylation of DNA, as well as polymorphisms and epigenetic events in the p53 gene. Finally, we discuss changes in gene expression using cDNA microarray techniques and changes in the expression of proteins and markers identified through mass spectrometry.


Cervical cancer; Biomarkers; Human papillomavirus; Pap smear; cervical intraepithelial neoplasia


Medicine and Pharmacology, Immunology and Allergy

Comments (1)

Comment 1
Received: 1 December 2020
Commenter: Mahendran Subramanian
Commenter's Conflict of Interests: Author
Comment: The paper was edited based on critical review by peers
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