Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Diuron on Embryo-Larval Development of Javanese Medaka (Oryzias javanicus, Bleeker 1854)

Version 1 : Received: 13 September 2020 / Approved: 13 September 2020 / Online: 13 September 2020 (15:33:58 CEST)

How to cite: Ibrahim, M.A.; Zulkifli, S.Z.; Azmai, M.N.A.; Mohamat-Yusuff, F.; Ismail, A. Effect of Diuron on Embryo-Larval Development of Javanese Medaka (Oryzias javanicus, Bleeker 1854). Preprints 2020, 2020090290 (doi: 10.20944/preprints202009.0290.v1). Ibrahim, M.A.; Zulkifli, S.Z.; Azmai, M.N.A.; Mohamat-Yusuff, F.; Ismail, A. Effect of Diuron on Embryo-Larval Development of Javanese Medaka (Oryzias javanicus, Bleeker 1854). Preprints 2020, 2020090290 (doi: 10.20944/preprints202009.0290.v1).

Abstract

Some herbicides exert hormetic or biphasic non-monotonic dose-response (NMDR), which is one of the major challenges for ecological risk assessment (ERA) of pesticides pollution. In this study, fish embryo toxicity test (FET) with Javanese medaka (Oryzias javanicus) to sublethal concentration of diuron was determined. Inverted U-shape heart rate was observed at 3 days post-exposure (dpe) and 7 dpe. However, at 13 dpe the heart rate (104 ± 2.90 heartbeat/min.) decreased in 10.00 mg.L-1 exposed-embryos. At 20 dpe, hatchability and survival rate were reduced in 5.00 mg.L-1 and 10.00 mg.L-1 exposed groups. Hormetic developmental deformities were observed in embryo-larvae of Javanese medaka. The results revealed a biphasic effect of low concentrations of diuron on some morphological and physiological features of Javanese medaka embryo-larvae, which might be attributed to endocrine disruption of this herbicide. Further studies to support these effects were recommended.

Subject Areas

hormesis; developmental toxicity; endocrine disruptor; herbicide; ecological risk assessment (ERA)

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