Preprint Essay Version 1 Preserved in Portico This version is not peer-reviewed

Possibility of Tapping NADH Regenerated from Ethylene Glycol Utilization Pathway for Cofactor Regeneration

Version 1 : Received: 31 August 2020 / Approved: 2 September 2020 / Online: 2 September 2020 (09:56:19 CEST)

How to cite: Ng, W. Possibility of Tapping NADH Regenerated from Ethylene Glycol Utilization Pathway for Cofactor Regeneration . Preprints 2020, 2020090039 (doi: 10.20944/preprints202009.0039.v1). Ng, W. Possibility of Tapping NADH Regenerated from Ethylene Glycol Utilization Pathway for Cofactor Regeneration . Preprints 2020, 2020090039 (doi: 10.20944/preprints202009.0039.v1).

Abstract

Although cofactor regeneration is an established system in biocatalysis, work remains in developing new and alternative cofactor regeneration systems with greater efficiency, ease of use, and higher atom economy. In addition, cofactor regeneration system only works if the cofactor regeneration reaction operates at similar kinetics compared to the biotransformation reaction. This meant that only specific cofactor regeneration system is capable of coupling with particular biotransformation reaction. This then leaves open the field for the development of a plethora of alternative cofactor regeneration systems each capable of coupling with different biotransformation reaction of different kinetics. This short write-up examines the possibility of tapping on the NADH regenerated from a two-step ethylene glycol utilization pathway. Current knowledge suggests that this angle has not been explored; thereby, opening up possibilities for future experimental investigations into the feasibility of coupling ethylene glycol utilization pathway with biotransformation reaction as a coupled cofactor regeneration system.

Subject Areas

NADH cofactor regeneration; ethylene glycol utilization; biocatalysis; atom economy; enzyme kinetics

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