Preprint Review Version 2 Preserved in Portico This version is not peer-reviewed

Monitoring the Redox Status in Multiple Sclerosis

Version 1 : Received: 29 July 2020 / Approved: 31 July 2020 / Online: 31 July 2020 (08:40:46 CEST)
Version 2 : Received: 28 August 2020 / Approved: 31 August 2020 / Online: 31 August 2020 (04:01:49 CEST)
Version 3 : Received: 21 September 2020 / Approved: 22 September 2020 / Online: 22 September 2020 (08:42:20 CEST)

How to cite: Tanaka, M.; Vécsei, L. Monitoring the Redox Status in Multiple Sclerosis. Preprints 2020, 2020070737 (doi: 10.20944/preprints202007.0737.v2). Tanaka, M.; Vécsei, L. Monitoring the Redox Status in Multiple Sclerosis. Preprints 2020, 2020070737 (doi: 10.20944/preprints202007.0737.v2).

Abstract

Worldwide, over 2.2 million people are suffered from multiple sclerosis (MS), a multifactorial demyelinating disease of the central nervous system. MS is characterized by multifocal inflammatory or demyelinating attacks associated with neuroinflammation and neurodegeneration. The blood, cerebrospinal fluid, and postmortem brain samples of MS patients evidenced the disturbance of reduction-oxidation (redox) homeostasis such as the alterations of oxidative and antioxidative enzyme activities and the presence of degradation products. This review article discussed the components of redox homeostasis including reactive chemical species, oxidative enzymes, antioxidative enzymes, and degradation products. The reactive chemical species covered frequently discussed reactive oxygen/nitrogen species, infrequently featured reactive chemicals such as sulfur, carbonyl, halogen, selenium, and nucleophilic species that potentially act as reductive as well as pro-oxidative stressors. The antioxidative enzyme systems covered the nuclear factor erythroid-2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) signaling pathway. The NRF2 and other transcriptional factors potentially become a biomarker sensitive to the initial phase of oxidative stress. Altered components of the redox homeostasis in MS were discussed in search of a diagnostic, prognostic, predictive, and/or therapeutic biomarker. Finally, monitoring a battery of reactive chemical species, oxidative enzymes, antioxidative enzymes and degradation products helps evaluate the redox status of MS patients, expediting prolongation of remission, prevention of relapse, and thus building personalized treatment plans.

Subject Areas

oxidative stress; redox; antioxidant; multiple sclerosis; biomarker; neurodegenerative disease; personalized medicine

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