Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Simulation of mTBI Utilizing White Matter Properties from MRE

Version 1 : Received: 15 July 2020 / Approved: 17 July 2020 / Online: 17 July 2020 (06:21:09 CEST)

How to cite: Madhukar, A.; Ostoja-Starzewski, M. Simulation of mTBI Utilizing White Matter Properties from MRE. Preprints 2020, 2020070366 (doi: 10.20944/preprints202007.0366.v1). Madhukar, A.; Ostoja-Starzewski, M. Simulation of mTBI Utilizing White Matter Properties from MRE. Preprints 2020, 2020070366 (doi: 10.20944/preprints202007.0366.v1).

Abstract

Tissues of the brain, especially white matter, are extremely heterogeneous - with constitutive response varying spatially. In this paper, we implement a high-resolution Finite Element (FE) head model where heterogeneities of white matter structures are introduced through Magnetic Resonance Elastography (MRE) experiments. Displacement of white matter under shear wave excitation is captured and the material properties determined though an inversion algorithm are directly used in the FE model. This approach is found to improve model predictions when compared to experimental results. In the first place, responses in the cerebrum near stiff structures such as the corpus callosum and corona radiata are markedly different compared with a homogenized material model. Additionally, the heterogeneities introduce additional attenuation of the shear wave due to wave scattering within the cerebrum.

Subject Areas

mTBI; MRI; MRE; brain wave dynamics; FE brain model

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