Madhukar, A.; Ostoja-Starzewski, M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling2020, 1, 225-241.
Madhukar, A.; Ostoja-Starzewski, M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling 2020, 1, 225-241.
Madhukar, A.; Ostoja-Starzewski, M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling2020, 1, 225-241.
Madhukar, A.; Ostoja-Starzewski, M. Modeling and Simulation of Head Trauma Utilizing White Matter Properties from Magnetic Resonance Elastography. Modelling 2020, 1, 225-241.
Abstract
Tissues of the brain, especially white matter, are extremely heterogeneous - with constitutive response varying spatially. In this paper, we implement a high-resolution Finite Element (FE) head model where heterogeneities of white matter structures are introduced through Magnetic Resonance Elastography (MRE) experiments. Displacement of white matter under shear wave excitation is captured and the material properties determined though an inversion algorithm are directly used in the FE model. This approach is found to improve model predictions when compared to experimental results. In the first place, responses in the cerebrum near stiff structures such as the corpus callosum and corona radiata are markedly different compared with a homogenized material model. Additionally, the heterogeneities introduce additional attenuation of the shear wave due to wave scattering within the cerebrum.
Keywords
mTBI; MRI; MRE; brain wave dynamics; FE brain model
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
