Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Narrative Review on Evaluation of Hypercoagulability State in Severe COVID-19 Patients with Background Risk Factors

Version 1 : Received: 4 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (07:41:24 CEST)

How to cite: Moghimi, M.; Khodadadi, K.; Mortazavi, Y. A Narrative Review on Evaluation of Hypercoagulability State in Severe COVID-19 Patients with Background Risk Factors. Preprints 2020, 2020060062 (doi: 10.20944/preprints202006.0062.v1). Moghimi, M.; Khodadadi, K.; Mortazavi, Y. A Narrative Review on Evaluation of Hypercoagulability State in Severe COVID-19 Patients with Background Risk Factors. Preprints 2020, 2020060062 (doi: 10.20944/preprints202006.0062.v1).

Abstract

COVID-19 induces coagulopathy at the base of SIC (sepsis-induced coagulopathy) and it is an important cause of death in the patients. Cytokine storm causes imbalance in coagulation and fibrinolytic system. A combination of hypercoagulability state, decrease or inhibition of fibrinolytic and endothelialopathy causes thromboembolic events. Underlined disease with a high rate of mortality in COVID-19 like diabetes, hypertension and some conditions like aging and obesity are the main disorders with hemostatic disturbance and increase of coagulopathy. Therefore, it seems that the combination of COVID-19 infection and these risk factors increase the risk of thromboembolic all together.

Subject Areas

Covid19; DIC; coagulopathy; Sars Covid; blood coagulation disorder

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