SARS-CoV-2 Virion Stabilization by Zn Binding

Silvia Morante; Giovanni La Penna; Giancarlo C. Rossi; Francesco Stellato

doi:10.20944/preprints202005.0423.v1

Preprint Communication Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 24 May 2020 / Approved: 26 May 2020 / Online: 26 May 2020 (08:14:47 CEST)
Version 2 : Received: 9 August 2020 / Approved: 9 August 2020 / Online: 9 August 2020 (22:08:56 CEST)

Zinc plays a crucial role in the process of virion maturation inside the host cell. The accessory Cys-rich proteins expressed in SARS-CoV-2 by genes ORF7a and ORF8 are likely involved in zinc binding and in interactions with cellular antigens activated by extensive disulfide bonds. In this report we provide a proof of concept for the feasibility of a structural study of orf7a and orf8 proteins. We make the point that lack of cellular zinc, or substitution thereof, might lead to a significant slowing down of viral maturation.

Sars-CoV2; Zn Finger; orf7a/orf8 and Theterin

Biology and Life Sciences, Biophysics

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SARS-CoV-2 Virion Stabilization by Zn Binding

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