Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Post Operative Acute Kidney Injury after HPB Surgeries – A Single Centre Retrospective Analysis

Version 1 : Received: 17 May 2020 / Approved: 18 May 2020 / Online: 18 May 2020 (17:29:02 CEST)

How to cite: Vasavada, B.B.; Patel, H. Post Operative Acute Kidney Injury after HPB Surgeries – A Single Centre Retrospective Analysis. Preprints 2020, 2020050306 (doi: 10.20944/preprints202005.0306.v1). Vasavada, B.B.; Patel, H. Post Operative Acute Kidney Injury after HPB Surgeries – A Single Centre Retrospective Analysis. Preprints 2020, 2020050306 (doi: 10.20944/preprints202005.0306.v1).

Abstract

Aim: Aim of our study was to evaluate incidence and causative factors for acute kidney injury in hepatopancreaticobiliary (HPB) surgeries. Material and Methods: All the HPB surgeries performed between April 2018 to March 2020, in our institution have been analysed for acute kidney injury. Acute kidney injury defined according to acute kidney injury network classification. Categorical variables were evaluated by chi square test and fisher t test wherever approptiate and continuous variables by Mann Whitney U test. Statistical analysis was done using SPSS version 23. P< 0.05 was considered significant. Results: We performed 195 HPB surgeries between April 2018 to March 2020, Which included 114 biliary surgeries, 57 liver surgeries and 23 pancreas surgeries. 10 patients developed Acute Kidney Injuries. (AKI) On Univariate analysis AKI was associated with open surgeries, intra operative hypotension and liver surgeries, higher ASA grade, increase operative time, more blood products used, higher CDC grade of surgery and more hospital stay before diagnosis of AKI. However on multivariate analysis only higher ASA score independently predicted Acute Kidney Injury. (p=0.003, odds ratio 15.659, 95% confidence interval 2.54-93.36). AKI was also significantly associated with mortality. (p <0.0001). Conclusion: Pre operative higher ASA grade independently predicted post operative acute kidney injury. Post operative AKI is significantly associated with mortality.

Subject Areas

acute kidney injury; HPB surgery; perioperative care; critical care

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