Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro

Version 1 : Received: 16 May 2020 / Approved: 18 May 2020 / Online: 18 May 2020 (04:18:39 CEST)
Version 2 : Received: 14 June 2020 / Approved: 15 June 2020 / Online: 15 June 2020 (06:44:57 CEST)

How to cite: Komoshvili, K.; Israel, K.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman Aronov, S. W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro. Preprints 2020, 2020050296 (doi: 10.20944/preprints202005.0296.v1). Komoshvili, K.; Israel, K.; Levitan, J.; Yahalom, A.; Barbora, A.; Liberman Aronov, S. W-Band Millimeter Waves Targeted Mortality of H1299 Human Lung Cancer Cells without Affecting Non-tumorigenic MCF-10A Human Epithelial Cells In Vitro. Preprints 2020, 2020050296 (doi: 10.20944/preprints202005.0296.v1).

Abstract

Therapeutically effective treatments of cancer are limited. To calibrate the efficiency of the novel technique we recently discovered to modulate cancer cell viability using tuned electromagnetic fields; H1299 human lung cancer cells were irradiated in a sweeping regime of W-band (75-105 GHz) millimeter waves (MMW) at 0.2 mW/cm2 (2 W/m2). Effects on cell morphology, cell death and senescence were examined and compared to that of non-tumorigenic MCF-10A human epithelial cells. MMW irradiation led to alterations of cell and nucleus morphology of H1299 cells, significantly increasing mortality and senescence over 14 days of observation. Extended irradiation of 10 minutes duration resulted in complete death of exposed H1299 cell population within two days, while healthy MCF-10A cells remained unaffected even after 16 minutes of irradiation under the same conditions. Irradiation effects were observed to be specific to MMW treated H1299 cells and absent in the control group of non-irradiated cells. MMW irradiation did not affect cell morphology of immortalized MCF-10A cells. Irradiation with low intensity MMW shows an antitumor effect on H1299 lung cancer cells. This method provides a novel treatment modality enabling targeted specificity for various types of cancers.

Subject Areas

W-band (75-105 GHz) MMW; H1299 human lung cancer cells; non-tumorigenic MCF-10A human epithelial cells; in vitro

Comments (2)

Comment 1
Received: 21 May 2020
Commenter: Abhilash baruah
The commenter has declared there is no conflict of interests.
Comment: Good job Scientist hope it will be soon available to treat Lungs cancer patient which is most common
+ Respond to this comment
Response 1 to Comment 1
Received: 25 May 2020
Commenter: Stella Liberman Aronov
The commenter has declared there is no conflict of interests.
Comment: Thank you for the comment... we are working on it... this work is preliminary results on cell line model.. we plan to examine the possible therapeutic effect of MMW in this spectrum on mice cancer model. Stella Liberman- Aronov, PhD

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 2
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.