Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Actualities on Diagnosis, Targeting and Treating Bone Metastases in Breast Cancer with Radiotherapy and New Drugs

Fabio Marazzi
,
Armando Orlandi
,
Stefania Manfrida
,
Valeria Masiello
* ORCID logo ,
Alba Di Leone
,
Mariangela Massaccesi
,
Francesca Moschella
,
Gianluca Franceschini
,
Emilio Bria
,
Maria Antonietta Gambacorta
,
Riccardo Masetti
,
Giampaolo Tortora
,
Vincenzo Valentini
Version 1 : Received: 1 May 2020 / Approved: 2 May 2020 / Online: 2 May 2020 (12:48:23 CEST)
Version 2 : Received: 14 August 2020 / Approved: 20 August 2020 / Online: 20 August 2020 (04:25:31 CEST)

A peer-reviewed article of this Preprint also exists.

Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers 2020, 12, 2390. Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Diagnosis and Treatment of Bone Metastases in Breast Cancer: Radiotherapy, Local Approach and Systemic Therapy in a Guide for Clinicians. Cancers 2020, 12, 2390.

Abstract

The standard of care for metastatic breast cancer (MBC) is systemic therapies with imbrication of focal treatment in case of symptomatology onset. Recently, thanks to implementation of radiological and metabolic exams and development of new target therapies, oligometastatic and oligoprogressive disease presentations are even more common, leading to a change of paradigm of focal treatments. In fact, acknowledgement of behaviour of disease in these setting of patients is carrying aim of radiotherapy towards modalities with radical intent. The aim of this literature review is to analyse available clinical data regarding disease behaviour, imaging, radiotherapy and chemo-radiotherapy integration outcomes for understanding bone metastasis from breast cancer and the potential impact of targeting it.

Keywords

bone metastasis; breast cancer; radiotherapy; diagnostic imaging; radiobiologic response; target therapy

Subject

Medicine and Pharmacology, Oncology and Oncogenics

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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