Preprint Review Version 1 This version is not peer-reviewed

Actualities on Diagnosis, Targeting and Treating Bone Metastases in Breast Cancer with Radiotherapy and New Drugs

Version 1 : Received: 1 May 2020 / Approved: 2 May 2020 / Online: 2 May 2020 (12:48:23 CEST)

How to cite: Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Actualities on Diagnosis, Targeting and Treating Bone Metastases in Breast Cancer with Radiotherapy and New Drugs. Preprints 2020, 2020050010 (doi: 10.20944/preprints202005.0010.v1). Marazzi, F.; Orlandi, A.; Manfrida, S.; Masiello, V.; Di Leone, A.; Massaccesi, M.; Moschella, F.; Franceschini, G.; Bria, E.; Gambacorta, M.A.; Masetti, R.; Tortora, G.; Valentini, V. Actualities on Diagnosis, Targeting and Treating Bone Metastases in Breast Cancer with Radiotherapy and New Drugs. Preprints 2020, 2020050010 (doi: 10.20944/preprints202005.0010.v1).

Abstract

The standard of care for metastatic breast cancer (MBC) is systemic therapies with imbrication of focal treatment in case of symptomatology onset. Recently, thanks to implementation of radiological and metabolic exams and development of new target therapies, oligometastatic and oligoprogressive disease presentations are even more common, leading to a change of paradigm of focal treatments. In fact, acknowledgement of behaviour of disease in these setting of patients is carrying aim of radiotherapy towards modalities with radical intent. The aim of this literature review is to analyse available clinical data regarding disease behaviour, imaging, radiotherapy and chemo-radiotherapy integration outcomes for understanding bone metastasis from breast cancer and the potential impact of targeting it.

Subject Areas

bone metastasis; breast cancer; radiotherapy; diagnostic imaging; radiobiologic response; target therapy

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